{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:45:58Z","timestamp":1778075158436,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Four outbreaks of leukoencephalomyelopathy in colonies of SPF cats on a long\u2010term diet of irradiated dry cat food were observed in the Netherlands between 1989 and 2001. As a primary defect in myelin formation was suspected to be the cause of the disease and myelin consists mainly of lipids and their fatty acids, we investigated the fatty acid composition of the white matter of the spinal cord of affected and control cats and of irradiated and non\u2010irradiated food. The irradiated food had low levels of alpha\u2010linolenic acid compared to linoleic acid as well as a high total omega\u20106:omega\u20103 ratio of 7:1 in the irradiated and of 2:1 in the non\u2010irradiated food. The white matter of the spinal cord showed low levels of linoleic acid and absence of alpha\u2010linolenic acid in affected cats as well as absence of lignoceric and nervonic acid in both affected and control cats. These abnormalities in fatty acid composition of the white matter of the spinal cord may reflect an increased need for alpha\u2010linolenic acid as a substrate for longer chain omega\u20103 fatty acids to compose myelin and thus indicate a particular species sensitivity to dietary deficiency in omega\u20103 polyunsaturated fatty acids, particularly alpha\u2010linolenic acid in cats. Our findings indicate that abnormalities in fatty acid metabolism in myelin play an essential role in the pathogenesis of this acquired form of leukoencephalomyelopathy in cats.<\/jats:p>","DOI":"10.1111\/jpn.13139","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T07:25:45Z","timestamp":1559892345000},"page":"1556-1563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Leukoencephalomyelopathy in cats linked to abnormal fatty acid composition of the white matter of the spinal cord and of irradiated dry cat food"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2803-657X","authenticated-orcid":false,"given":"Ted S. G. A. M.","family":"van den Ingh","sequence":"first","affiliation":[{"name":"TCCI Consultancy Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy C. M.","family":"Grinwis","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0740-1600","authenticated-orcid":false,"given":"Ronald Jan","family":"Corbee","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies in Companion Animals \u2013 Clinical Nutrition, Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.03.058"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.871"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb00906.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813506917"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002605"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.44-6-912"},{"key":"e_1_2_6_8_1","first-page":"61","article-title":"Effects of gamma irradiation and pasteurization on the nutritive composition of commercially available animal diets","volume":"47","author":"Caulfield C. 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