{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:54:05Z","timestamp":1785545645541,"version":"3.56.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thiamine is recognized as a cofactor for many enzymes involved in intermediary metabolism responsible for energy production. Animal model of thiamine deficiency (TD) included direct evaluation of glucose uptake by estimation of <jats:sup>3<\/jats:sup>H\u2010deoxyglucose transport across red blood cells membranes and \u03b2\u2010oxidation of fatty acids in isolated leucocytes. Feeding of animals with the thiamine\u2010deficient diet (0.018\u00a0mg\/kg diet) for 30\u00a0days resulted in disturbances in energy production. The thiamine intake was limited not only by vitamin B<jats:sub>1<\/jats:sub> deficiency in the diet, but also by time\u2010dependent drop of feed consumption by rats fed this diet. At the end of experiment, diet consumption in this group of rats was 52% lower than in the control group. This was accompanied by low glucose uptake by erythrocytes of rats suffering vitamin B<jats:sub>1<\/jats:sub> deficiency for longer time. At the end of experimental period, glucose uptake was over 2 times lower in TD erythrocytes than in control RBC. Such drop of energy production was not compensated by delivery of energy from fatty acid degradation. In leucocytes from TD rats, the \u03b2\u2010oxidation was also suppressed. Observed significant decrease of serum insulin from 2.25\u00a0\u00b1\u00a00.25\u00a0ng\/ml (day 0) to 1.94\u00a0\u00b1\u00a00.17\u00a0ng\/ml (day 30) might have significant impact on observed energy production disorders. The results from this study indicate that the thiamine deficiency significantly reduces feed intake and causes modest abnormalities in glucose and fatty acid utilization.<\/jats:p>","DOI":"10.1111\/jpn.13146","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T09:31:05Z","timestamp":1561973465000},"page":"1629-1635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Thiamine deficiency affects glucose transport and \u03b2\u2010oxidation in rats"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3008-4917","authenticated-orcid":false,"given":"Miko\u0142aj Antoni","family":"Gralak","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences, Faculty of Veterinary Medicine Warsaw University of Life Sciences\u2010SGGW Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1637-5889","authenticated-orcid":false,"given":"Bogdan","family":"D\u0119bski","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Faculty of Veterinary Medicine Warsaw University of Life Sciences\u2010SGGW Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8582-8306","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Drywie\u0144","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Faculty of Human Nutrition and Consumer Sciences Warsaw University of Life Sciences\u2010SGGW Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198405000-00006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1245-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e32835724a1"},{"issue":"2","key":"e_1_2_6_5_1","first-page":"22","article-title":"Studies on experimental thiamine deficiency in male Wistar rats","volume":"5","author":"Balaji G.","year":"2015","journal-title":"International Journal of Life Science and Pharma Research"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-3062-y"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.3.641"},{"issue":"1","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0021-9258(18)70566-8","article-title":"The effect of thiamine deficiency on the glucose oxidative pathway of rat erythrocytes","volume":"230","author":"Brin M.","year":"1958","journal-title":"The Journal of Biological Chemistry"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-014-9712-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314939111"},{"key":"e_1_2_6_11_1","volume-title":"Reports of the Scientific Committee for Food. 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