{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:08:12Z","timestamp":1778918892626,"version":"3.51.4"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019MC038"],"award-info":[{"award-number":["ZR2019MC038"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to evaluate the effects of zearalenone (ZEA) and estradiol benzoate (EB) on stress injury and uterine development in post\u2010weaning gilts. Thirty healthy post\u2010weaning female gilts (Duroc\u00a0\u00d7\u00a0Landrace\u00a0\u00d7\u00a0Large White) aged 28\u201332\u00a0days were randomly allocated to three treatments as follows: (a) basal diet (Control), (b) basal diet plus 1.0\u00a0mg\/kg purified ZEA (ZEA) and (c) basal diet plus 0.75\u00a0ml (1.5\u00a0mg) EB per pig at 3\u2010days intervals by intramuscular injection (EB). The serum estradiol (E<jats:sub>2<\/jats:sub>), the final and the increased vulvar area, uterine index, thickness of the myometrium and endometrium, and protein expression of heat shock protein 70 (HSP70) in ZEA group were higher than those in the control group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), but lower than those in the EB group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). The serum luteinizing hormone in ZEA group was lower than that of the control group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), but higher than that in the EB group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Higher serum follicle\u2010stimulating hormone and progesterone were observed in the ZEA and control groups than those in the EB group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). The serum glutathione peroxidase activity in the ZEA group was lower than that in the control and EB groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), and the malondialdehyde in the ZEA group was higher than that in the control and EB groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Moreover, the relative mRNA and protein expression of growth hormone receptor (GHR) and relative mRNA expression of HSP70 in the ZEA and EB groups were higher than those in the control group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). In conclusion, both ZEA (1.0\u00a0mg\/kg) and EB (1.5\u00a0mg at 3\u00a0days intervals by intramuscular injection) stimulated vulvar swelling and uterine hypertrophy by disordering serum hormones and up\u2010regulating GHR expression, and induced stress by different mechanisms in this study. Furthermore, the observed up\u2010regulating HSP70 expression challenged by ZEA or EB may be part of the mechanism to resist stress injury.<\/jats:p>","DOI":"10.1111\/jpn.13195","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T14:54:09Z","timestamp":1567608849000},"page":"1885-1894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Comparative study of stress response, growth and development of uteri in post\u2010weaning gilts challenged with zearalenone and estradiol benzoate"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-7893","authenticated-orcid":false,"given":"Min","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Animal Sciences and Technology College of Shandong Agricultural University Taian P. R. 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