{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:30:10Z","timestamp":1791916210722,"version":"4.3.4"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the effect of <jats:italic>Lactobacillus plantarum<\/jats:italic> strain 299v on gut health in suckling piglets. Sixty newborn piglets were assigned to control and probiotic treatments, with three litters per treatment (ten piglets\/litter). From days 1 to 20 of life, piglets were orally administered a placebo of 0.1% peptone or 1.0\u00a0\u00d7\u00a0\u00a010<jats:sup>10\u00a0<\/jats:sup>CFU <jats:italic>L. plantarum<\/jats:italic> 299v daily. Six piglets per treatment were sacrificed on day 20, and intestinal tissues (including duodenum, jejunum, ileum and colon) and the intestinal contents from colon segments were collected. The results demonstrated that piglets treated with <jats:italic>L. plantarum<\/jats:italic> 299v had a lower diarrhoea incidence than the controls. <jats:italic>L. plantarum<\/jats:italic> 299v administration significantly increased the ratio of the villus height to the crypt depth in the jejunum and ileum, as well as the mRNA expression of jejunal <jats:italic>occludin<\/jats:italic> and ileal <jats:italic>zonula occludens 1<\/jats:italic> (<jats:italic>ZO\u20101<\/jats:italic>). The <jats:italic>L. plantarum<\/jats:italic> treatment also increased the mRNA abundance of porcine \u03b2\u2010defensin 2 (<jats:italic>pBD2<\/jats:italic>) and <jats:italic>pBD3<\/jats:italic> in the jejunum and ileum and of toll\u2010like receptors (TLRs), such as <jats:italic>TLR2<\/jats:italic>, <jats:italic>TLR4<\/jats:italic>, <jats:italic>TLR6<\/jats:italic> and <jats:italic>TLR9<\/jats:italic> in the ileum, and significantly upregulated the mRNA abundances of ileal <jats:italic>pBD1<\/jats:italic> and colonic <jats:italic>TLR4<\/jats:italic>. Additionally, the <jats:italic>L. plantarum<\/jats:italic> 299v treatment significantly changed the structure of the colonic microbiota, as evidenced by the obvious increases in the relative abundances of the phyla <jats:italic>Firmicutes<\/jats:italic> and <jats:italic>Actinobacteria<\/jats:italic> and of the\u00a0genus <jats:italic>Lactobacillus<\/jats:italic>. Our findings indicate that <jats:italic>L. plantarum<\/jats:italic> 299v facilitates the gut health of suckling piglets, probably by improving the intestinal morphology and intestinal barrier function and by modifying the structure of the gut microbiota.<\/jats:p>","DOI":"10.1111\/jpn.13198","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T15:16:46Z","timestamp":1568042206000},"page":"1908-1918","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Effects of <i>Lactobacillus plantarum<\/i> on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9260-9099","authenticated-orcid":false,"given":"Qi","family":"Wang","sequence":"first","affiliation":[{"name":"Chongqing Academy of Animal Sciences Chongqing China"},{"name":"Key Laboratory of Pig Industry Sciences Chongqing Key Laboratory of Pig Industry Sciences Ministry of Agriculture Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9371-0145","authenticated-orcid":false,"given":"Qian","family":"Sun","sequence":"additional","affiliation":[{"name":"Chongqing Academy of Animal Sciences Chongqing China"},{"name":"College of Animal Science Southwest University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-8983","authenticated-orcid":false,"given":"Renli","family":"Qi","sequence":"additional","affiliation":[{"name":"Chongqing Academy of Animal Sciences Chongqing China"},{"name":"Key Laboratory of Pig Industry Sciences Chongqing Key Laboratory of Pig Industry Sciences Ministry of Agriculture Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4927-741X","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Chongqing Academy of Animal Sciences Chongqing China"},{"name":"Key Laboratory of Pig Industry Sciences Chongqing Key Laboratory of Pig Industry Sciences Ministry of Agriculture Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8530-7225","authenticated-orcid":false,"given":"Xiaoyu","family":"Qiu","sequence":"additional","affiliation":[{"name":"Chongqing Academy of Animal Sciences Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9538-8292","authenticated-orcid":false,"given":"Zuohua","family":"Liu","sequence":"additional","affiliation":[{"name":"Chongqing Academy of Animal Sciences Chongqing China"},{"name":"Key Laboratory of Pig Industry Sciences Chongqing Key Laboratory of Pig Industry Sciences Ministry of Agriculture Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4114-3414","authenticated-orcid":false,"given":"Jinxiu","family":"Huang","sequence":"additional","affiliation":[{"name":"Chongqing Academy of Animal Sciences Chongqing China"},{"name":"Key Laboratory of Pig Industry Sciences Chongqing Key Laboratory of Pig Industry Sciences Ministry of Agriculture Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/9478630","article-title":"Probiotic species in the modulation of gut microbiota: An overview","volume":"2018","author":"Azad M. 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