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The hypothesis was that it is possible to predict MMA by measuring ketone bodies and bone markers. Blood samples from 175 sows were taken within 72\u00a0hr after farrowing. Serum was analysed for 25\u2010hydroxyvitamin D (25\u2010(OH)\u2010D), serum crosslaps (CTX\u2010I), osteocalcin (OC), alkaline phosphatase (ALP), calcium (Ca), magnesium (Mg), phosphorus (P), parathyroid hormone (PTH), triglycerides (TG), beta\u2010hydroxybutyric acid (BHB), tumour necrosis factor\u2010alpha (TNF\u2010\u03b1) and haptoglobin. Spontaneous urine was collected, and pH value was measured in addition to Ca and P. A proximate analysis of the sows\u2019 diets was performed. Age, litter size, body condition score (BCS) and clinical signs of MMA were recorded for each sow. A multivariable logistic regression was undertaken with disease status (MMA or healthy) as the dependent variable. Significance was accepted at <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05. MMA sows had a poorer BCS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) in relation to healthy sows. Age and number of piglets did not differ. MMA sows showed increased serum CTX\u2010I (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.004) and decreased serum OC (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Concentrations of P (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.007), activity of ALP (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002) and BHB (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.019) as well as TNF\u2010\u03b1 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and haptoglobin (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.048) concentrations were increased in MMA sows. No difference in urinary pH value between MMA and healthy sows was found. Our results are in accordance with the known fact that sows are in an extreme catabolic state peripartum. Bone metabolism in MMA sows is much more negatively affected than in healthy sows post\u2010partum, due to inflammatory processes shown by higher concentrations of pro\u2010inflammatory cytokines.<\/jats:p>","DOI":"10.1111\/jpn.13201","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T07:44:31Z","timestamp":1571730271000},"page":"138-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Influence of mastitis metritis agalactia (MMA) on bone and fat metabolism"],"prefix":"10.1111","volume":"105","author":[{"given":"Niklas A.","family":"Karst","sequence":"first","affiliation":[{"name":"Vetsuisse\u2010Faculty Institute of Animal Nutrition University of Zurich  Zurich Switzerland"},{"name":"Vetsuisse\u2010Faculty Centre for Clinical Studies University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xaver","family":"Sidler","sequence":"additional","affiliation":[{"name":"Division of Swine Medicine Department of Farm Animals Vetsuisse\u2010Faculty University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4292-8515","authenticated-orcid":false,"given":"Annette","family":"Liesegang","sequence":"additional","affiliation":[{"name":"Vetsuisse\u2010Faculty Institute of Animal Nutrition University of Zurich  Zurich Switzerland"},{"name":"Vetsuisse\u2010Faculty Centre for Clinical Studies University of Zurich  Zurich Switzerland"},{"name":"Centre for Applied Biotechnology and Molecular Medicine University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"5","article-title":"Porcine ketosis: A case report and literature summary","volume":"2","author":"Alsop J. 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