{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:35:12Z","timestamp":1787495712475,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31672511"],"award-info":[{"award-number":["31672511"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Weaning may cause oxidative injury, immune response impairment, apoptosis and other injuries in piglets. Oxidative and endoplasmic reticulum stress (ERS) can elicit inflammatory responses, and persistent oxidative and ERS also may lead to apoptotic cascades, which is associated with the pathogenesis of multiple diseases. \u03b2\u2010carotene, a natural carotenoid, has potential anti\u2010inflammatory and antioxidant functions. However, the effect of \u03b2\u2010carotene on apoptosis in weaned piglets and the detailed molecular mechanism remain unclear. In this study, we found that \u03b2\u2010carotene decreased malondialdehyde (MDA) levels and increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH\u2010Px) in piglet serum. \u03b2\u2010carotene could inhibit the mRNA levels of caspase\u20103 significantly, but had no significant inhibitory effect of the mRNA levels of caspase\u20109 and caspase\u201012 in the piglet jejunum. In addition, \u03b2\u2010carotene decreased the activation of GRP78, CHOP, and JNK\/p38 MAPK and the ratio of Bax\/Bcl\u20102. Furthermore, \u03b2\u2010carotene had a significant influence on the activation of ERS and apoptosis\u2010related signals in TG\u2010induced IPEC\u2010J2. In the present study, \u03b2\u2010carotene pre\u2010treatment attenuated the ratio of Bax\/Bcl\u20102 and prevented TG\u2010induced increases in the level of PERK\u2010CHOP and IRE1\u2010JNK\/p38 MAPK pathway activation in a dose\u2010dependent manner. Overall, these findings indicate that \u03b2\u2010carotene may protect weaning\u2010induced apoptosis through inhibiting ERS.<\/jats:p>","DOI":"10.1111\/jpn.13216","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T05:19:26Z","timestamp":1569907166000},"page":"280-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["\u03b2\u2010carotene attenuates weaning\u2010induced apoptosis via inhibition of PERK\u2010CHOP and IRE1\u2010JNK\/p38 MAPK signalling pathways in piglet jejunum"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-2620","authenticated-orcid":false,"given":"Ruonan","family":"Li","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Jilin Agricultural University Changchun 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