{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:34:31Z","timestamp":1773027271979,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["31972594"],"award-info":[{"award-number":["31972594"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972594"],"award-info":[{"award-number":["31972594"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the effect and molecular mechanism of methionine (Met) on the growth of hair follicles (HFs) in Rex rabbits. A total of 200 weaning Rex rabbits were divided into four groups and fed varying levels of Met\u2010supplemented diets. We measured the HF density on dorsal skin and the Wnt\/\u03b2\u2010catenin pathway protein expression level. Meanwhile, whole HFs were isolated from Rex rabbit skins and cultured with Met in vitro to measure hair shaft growth. The relationship between Met and the Wnt\/\u03b2\u2010catenin signalling pathway was also characterized by using the Wnt\/\u03b2\u2010catenin signalling inhibitor, XAV\u2010939. The results showed that the addition of dietary Met could significantly increase the HF density on dorsal skin (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) and enhance the protein expression level of Wnt10b (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), \u03b2\u2010catenin (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) and DSH (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Methionine stimulation could also prolong the hair shafts growth in vitro (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). And inhibition of Wnt\/\u03b2\u2010catenin signalling using XAV\u2010939 could eliminate this phenomenon. In summary, Met can increase the density of HFs on dorsal skin in vitro and prolong the hair shaft growth of HFs in vivo via the Wnt\/\u03b2\u2010catenin signalling pathway.<\/jats:p>","DOI":"10.1111\/jpn.13238","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T04:50:00Z","timestamp":1573879800000},"page":"379-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Methionine promotes the development of hair follicles via the Wnt\/\u03b2\u2010catenin signalling pathway in Rex rabbits"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-8478","authenticated-orcid":false,"given":"Yanli","family":"Zhu","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Shandong Agricultural University Taian China"},{"name":"Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention Taian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shandong Agricultural University Taian China"},{"name":"Department of Teachers and Education Taishan University Taian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongli","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shandong Agricultural University Taian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-7759","authenticated-orcid":false,"given":"Gongyan","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shandong Agricultural University Taian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5670-8038","authenticated-orcid":false,"given":"Fuchang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Shandong Agricultural University Taian China"},{"name":"Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention Taian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00167-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2017.06.003"},{"key":"e_1_2_7_4_1","first-page":"443","article-title":"Influence of dietary protein level and the amino acids methionine and lysine on leather properties of blue fox (Alopex lagopus) pelts","volume":"56","author":"Dahlman T.","year":"2002","journal-title":"Archives of Animal Nutrition"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4141\/A02-078"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1079\/9781845936693.0000"},{"key":"e_1_2_7_7_1","first-page":"71","volume-title":"An outline of pathways in amino acid metabolism. 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