{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T14:51:07Z","timestamp":1772203867024,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T00:00:00Z","timestamp":1577318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010038","name":"Earmarked Fund for China Agriculture Research System","doi-asserted-by":"publisher","award":["CARS\u201035"],"award-info":[{"award-number":["CARS\u201035"]}],"id":[{"id":"10.13039\/501100010038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies showed heat stress reduces body weight gain and feed intake associated with damaged intestinal barrier function, and <jats:sc>l<\/jats:sc>\u2010arginine (L\u2010Arg) enhanced intestinal barrier function in young animals under stress. The aim of this study was to evaluate effects of L\u2010Arg on serum hormones, intestinal morphology, nutrients absorption and epithelial barrier functions in finishing pigs with heat stress. Forty\u2010eight finishing pigs (Landrace) were balanced for sex and then randomly assigned to six groups: TN group, thermal neutral (22\u00b0C, ~80% humidity) with a basal diet; HS group, heat stress (cyclical 35\u00b0C for 12\u00a0hr and 22\u00b0C for 12\u00a0hr, ~80% humidity) with a basal diet; PF group, thermal neutral (22\u00b0C, ~80% humidity) and pair\u2010fed with the HS; the TNA, HSA and PFA groups were the basal diet of TN group, HS group and PF group supplemented with 1% L\u2010Arg. Results showed that HS decreased (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) the thyroxine concentrations and increased (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) the insulin concentrations in serum compared with the TN group, but 1% L\u2010Arg had no significant effects on them. Both HS and PF significantly increased (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) the mRNA expression of cationic amino acid transporters (CAT1 and CAT2) and decreased the mRNA expression of solute carrier family 5 member 10 (SGLT1) in the jejunum compared with the TN group. Compared with the TN group, HS reduced the expression of tight junction (TJ) protein zonula occluden\u20101 (ZO\u20101) and occludin, but PF only decreased ZO\u20101 expression in the jejunum. Results exhibited that dietary supplementation with 1% L\u2010Arg improved the intestinal villous height, the ratio of villous height to crypt depth, and the expression of occludin and porcine beta\u2010defensin 2 (pBD2) in the jejunum of intermittent heat\u2010treated finishing pigs. In conclusion, dietary supplementation with 1% L\u2010Arg could partly attenuate the intermittent heat\u2010induced damages of intestinal morphology and epithelial barrier functions in finishing pigs.<\/jats:p>","DOI":"10.1111\/jpn.13277","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T05:32:59Z","timestamp":1577424779000},"page":"1134-1143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effects of dietary supplementation with <scp>l<\/scp>\u2010arginine on the intestinal barrier function in finishing pigs with heat stress"],"prefix":"10.1111","volume":"104","author":[{"given":"Hongbo","family":"Yi","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China of Ministry of Agriculture State Key Laboratory of Livestock and Poultry Breeding Guangdong Public Laboratory of Animal Breeding and Nutrition Guangdong Key Laboratory of Animal Breeding and Nutrition Institute of Animal Science Guangdong Academy of Agricultural Sciences Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxia","family":"Xiong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China of Ministry of Agriculture State Key Laboratory of Livestock and Poultry Breeding Guangdong Public Laboratory of Animal Breeding and Nutrition Guangdong Key Laboratory of Animal Breeding and Nutrition Institute of Animal Science Guangdong Academy of Agricultural Sciences Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiwen","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China of Ministry of Agriculture State Key Laboratory of Livestock and Poultry Breeding Guangdong Public Laboratory of Animal Breeding and Nutrition Guangdong Key Laboratory of Animal Breeding 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Institute of Animal Science Guangdong Academy of Agricultural Sciences Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongyong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China of Ministry of Agriculture State Key Laboratory of Livestock and Poultry Breeding Guangdong Public Laboratory of Animal Breeding and Nutrition Guangdong Key Laboratory of Animal Breeding and Nutrition Institute of Animal Science Guangdong Academy of Agricultural Sciences Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5084-9596","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China of Ministry of Agriculture State Key Laboratory of Livestock and Poultry Breeding Guangdong Public Laboratory of Animal Breeding and 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