{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:52Z","timestamp":1787015692338,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2017JJ1020"],"award-info":[{"award-number":["2017JJ1020"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Intestinal villi are important structures for digesting and absorbing nutrients. It was hypothesized that intestinal villous height (VH) is related to growth performance, and that VH is associated with digestive and absorptive capabilities in piglets. Sixty 21\u2010d\u2010old weaned piglets were fed identical diets for 28\u00a0days. The piglets were grouped according to jejunal or ileal VH at the end of the experiment, including short, middle and high VH groups. The final BW (quadratic,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.003), ADG (liner,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.052; quadratic,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.030) and G: F (liner,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.074; quadratic,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.005) were greater in higher VH piglets compared with the shorter VH piglets. Significant linear relationships were recorded between jejunal VH and maltase (linear,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.003) and sucrase (linear,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.004) activities. Besides, jejunal VH was significantly associated with maltase (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.357,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.007), sucrase (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.394,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.003) and alkaline phosphate (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.288,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.033) activities. Jejunal\n                    <jats:italic>Slc1a1<\/jats:italic>\n                    (linear,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.004) mRNA expression increased as VH increased, while\n                    <jats:italic>Slc7a1<\/jats:italic>\n                    (linear,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.007) expression decreased as VH increased, and\n                    <jats:italic>Slc1a1<\/jats:italic>\n                    (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.292,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.031) expression was positively related to VH. In the ileum,\n                    <jats:italic>Slc5a1<\/jats:italic>\n                    (linear,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.002) and\n                    <jats:italic>Slc1a1<\/jats:italic>\n                    (linear,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.001) expression increased as VH increased, whereas\n                    <jats:italic>Slc7a1<\/jats:italic>\n                    (linear,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.045) expression decreased as VH increased. A positive relationship between ileal VH and\n                    <jats:italic>Slc5a1<\/jats:italic>\n                    (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.331,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.018),\n                    <jats:italic>Slc1a1<\/jats:italic>\n                    (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.444,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.001) and\n                    <jats:italic>Slc6a19<\/jats:italic>\n                    (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.314,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.026), respectively, was established. Additionally,\n                    <jats:italic>Slc7a9<\/jats:italic>\n                    (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.0271,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.057) expression tended to be positively associated with VH in ileum. In conclusion, the growth performance of piglets increased with increasing VH, which may via affecting mucosal enzymes activities and nutrient transporters\u2019 mRNA expression.\n                  <\/jats:p>","DOI":"10.1111\/jpn.13299","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T07:05:01Z","timestamp":1578985501000},"page":"606-615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["The relationship between villous height and growth performance, small intestinal mucosal enzymes activities and nutrient transporters expression in weaned piglets"],"prefix":"10.1111","volume":"104","author":[{"given":"Min","family":"Wang","sequence":"first","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human Health College of Life Sciences Hunan Normal University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Yang","sequence":"additional","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human Health College of Life Sciences Hunan Normal University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4024-2341","authenticated-orcid":false,"given":"Qiye","family":"Wang","sequence":"additional","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human Health College of Life Sciences Hunan Normal University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human Health College of Life Sciences Hunan Normal University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Huang","sequence":"additional","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human Health College of Life Sciences Hunan Normal University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human Health College of Life Sciences Hunan Normal University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Ding","sequence":"additional","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human Health College of Life Sciences 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