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Seven hundred and twenty healthy breeding hens were randomly assigned to four treatments; each treatment was replicated six times with 30 hens each. Broken rice and soybean meal were adopted for the basal diet and added with 0 (control group), 20, 40 and 80\u00a0mg\/kg lycopene respectively. Gene expression profile of the liver induced by lycopene and expression of genes related to fat metabolism in hens liver and intestine were analysed after 42\u2010day feeding trial including 7\u2010day pre\u2010feeding period and 35\u2010day formal period. The genes involved in fat metabolism were analysed, and we found that lycopene significantly increased the expression of <jats:italic>PGC1\u03b1<\/jats:italic>, <jats:italic>PPAR\u03b1<\/jats:italic>, <jats:italic>RXR\u03b1<\/jats:italic> and <jats:italic>RAR\u03b1<\/jats:italic> in the liver, <jats:italic>PPAR\u03b3<\/jats:italic>, <jats:italic>RXR\u03b1<\/jats:italic> and <jats:italic>RXR\u03b3<\/jats:italic> in the jejunum, and <jats:italic>RAR\u03b1<\/jats:italic> in the duodenum (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05); reduced the expression of <jats:italic>FABP1<\/jats:italic> and <jats:italic>FABP10<\/jats:italic> in the liver, and <jats:italic>FATP4<\/jats:italic> in the jejunum (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). By analysing gene expression profile, 158 differentially expressed genes (DEGs) including 69 up\u2010regulated genes and 89 down\u2010regulated genes were obtained between control group and 40\u00a0mg\/kg group. KEGG pathway analysis was performed on all DEGs, and 5 pathways were obtained. In conclusion, lycopene can affect the expression of related genes, and this may be one of the reasons that lycopene can regulate fat metabolism.<\/jats:p>","DOI":"10.1111\/jpn.13344","type":"journal-article","created":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T04:57:17Z","timestamp":1584161837000},"page":"936-945","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lycopene supplementation regulates the gene expression profile and fat metabolism of breeding hens"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-0613","authenticated-orcid":false,"given":"Hanchen","family":"Tian","sequence":"first","affiliation":[{"name":"College of Animal Science South China Agricultural University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangbin","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science South China Agricultural University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Animal Science South China Agricultural University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaokun","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science South China Agricultural University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Deng","sequence":"additional","affiliation":[{"name":"College of Animal Science South China Agricultural University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewu","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science South China Agricultural University Guangzhou 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