{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T17:13:21Z","timestamp":1750871601970,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous research documented that furosemide negatively impacted calcium balance for 3\u00a0days but did not determine when calcium balance returned to baseline. This study hypothesized that furosemide's impact on calcium would return to control values before 7\u00a0days post\u2010administration. Ten mature geldings were assigned to either control (CON,<jats:italic>n<\/jats:italic>\u00a0=\u00a05) or treatment (FUR,<jats:italic>n<\/jats:italic>\u00a0=\u00a05) for the first of two 8\u2010day total collections in crossover design. Treatment horses received one administration of furosemide (1\u00a0mg\/kg, IV). A 10% sample of pooled faeces and urine from each day was kept. Calcium concentrations in hay, faeces and urine were determined by an atomic absorption spectrophotometer. Data were analysed using mixed\u2010model\u2010repeated measures ANOVA to determine influence of day and treatment. For urine output, FUR urinated twice as much during the 24\u00a0hr after administration than CON (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Horses in FUR excreted more urinary calcium 24\u2010hr post\u2010administration as compared to CON (9.3\u00a0\u00b1\u00a01.0 and 4.2\u00a0\u00b1\u00a01.0\u00a0g, respectively;<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Calcium balance in FUR was more negative on day 1 than day 3 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Faecal calcium concentrations remained the same from day 1 to day 7 in CON (6.3\u00a0\u00b1\u00a01.3 and 5.5\u00a0\u00b1\u00a01.3\u00a0g\/kg, respectively;<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.10) but were lower in FUR on day 7 as compared to day 1 (4.8\u00a0\u00b1\u00a01.3 and 7.3\u00a0\u00b1\u00a01.3\u00a0g\/kg, respectively;<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), indicating a potential mechanism to restore calcium balance. These findings corroborate previous studies on furosemide and calcium balance and provide evidence for a possible mechanism to recover net calcium losses after furosemide administration. Since calcium balance returns to baseline in 3\u00a0days and previous results\u00a0have examined frequent, long\u2010term use, furosemide may not negatively impact bone mineral content even if used over long periods.<\/jats:p>","DOI":"10.1111\/jpn.13348","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T21:21:26Z","timestamp":1584566486000},"page":"946-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Furosemide administration results in a transient alteration in calcium balance in mature horses"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9689-5520","authenticated-orcid":false,"given":"Abby","family":"Pritchard","sequence":"first","affiliation":[{"name":"Department of Animal Science Michigan State University East Lansing Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-5731","authenticated-orcid":false,"given":"Brian D.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Animal Science Michigan State University East Lansing Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cara","family":"Robison","sequence":"additional","affiliation":[{"name":"Department of Animal Science Michigan State University East Lansing Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly","family":"Spooner","sequence":"additional","affiliation":[{"name":"Department of Horse Science Middle Tennessee University Murfreesboro Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00032.2017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-0233(03)00054-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2527\/1990.68103152x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2006.tb05547.x"},{"issue":"11","key":"e_1_2_8_6_1","first-page":"1899","article-title":"Influence of furosemide treatment on fluid and electrolyte balance in horses","volume":"49","author":"Freestone J. 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