{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:41:41Z","timestamp":1789342901668,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T00:00:00Z","timestamp":1586649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present trial was conducted to evaluate the beneficial role of some feed additives (potassium sorbate; Sor, hydrated sodium calcium almuniosilicate; Hsc and <jats:sc>l<\/jats:sc>\u2010methionine; L\u2010M) in attenuating the hepatic and renal toxicity of aflatoxin B1 (AFB1) in rabbits. A total number of 72 NZW growing rabbits (5\u00a0week\u2010old) were divided into six experimental groups (four replicates with three rabbits each) as follows: control group, AFB1 group (supplemented with AFB1 0.3\u00a0mg\/kg diet), AFB1\u00a0+\u00a0Sor group (AFB1 0.3\u00a0mg\/kg diet\u00a0+\u00a0Sor 2\u00a0g\/kg diet), AFB1\u00a0+\u00a0Hsc group (AFB1 0.3\u00a0mg\/kg diet\u00a0+\u00a0Hsc 5\u00a0g\/kg diet), AFB1\u00a0+\u00a0L\u2010M group (AFB1 0.3\u00a0mg\/kg diet\u00a0+\u00a0L\u2010M 8\u00a0g\/kg diet) and AFB1\u00a0+\u00a0Mix group (AFB1 0.3\u00a0mg\/kg diet\u00a0+\u00a02 Sor\u00a0+\u00a05 Hsc\u00a0+\u00a08 L\u2010M g\/kg diet). Serum levels of total protein, albumin and globulin were significantly reduced by AF. AF increased the serum activity of aspartate aminotransferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP) enzymes. While, they were reduced in AF\u00a0+\u00a0Sor and AF\u00a0+\u00a0Mix groups compared with AF group. AF increased the level of cystatin C and Beta\u20102 microglobulin (BMG). All other supplements significantly reduced the level of cystatin C than AF; however, this reduction was more pronounced in AF\u2010L\u2010M group. AF\u00a0+\u00a0Sor, AF\u00a0+\u00a0L\u2010M and AF\u00a0+\u00a0Mix equally reduced the BMG level than AF and AF\u00a0+\u00a0HSc, however, still higher than control. AF elevated the total cholesterol (TC) and LDL\u2010cholesterol levels. A significant reduction in HDL cholesterol was seen in AF group. Additionally, AF induced pathological alterations in the liver and kidney of exposed rabbits on the other hands, the three additives separately or in mix attenuated the Af\u2010induced alterations. In conclusion, the dietary supplementation of Sor, L\u2010M, Hsc or their mixture was effective in ameliorating the negative effects of AFB1 on liver and kidney function and structure in rabbits with more better improvement obtained by Sor or L\u2010M separately.<\/jats:p>","DOI":"10.1111\/jpn.13359","type":"journal-article","created":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T10:54:28Z","timestamp":1586688868000},"page":"1343-1350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy of some feed additives to attenuate the hepato\u2010renal damage induced by aflatoxin B1 in rabbits"],"prefix":"10.1111","volume":"104","author":[{"given":"Ismail E.","family":"Ismail","sequence":"first","affiliation":[{"name":"Poultry Department Faculty of Agriculture Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayada R.","family":"Farag","sequence":"additional","affiliation":[{"name":"Forensic Medicine and Toxicology Department Veterinary Medicine Faculty Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8020-0971","authenticated-orcid":false,"given":"Mahmoud","family":"Alagawany","sequence":"additional","affiliation":[{"name":"Poultry Department Faculty of Agriculture Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemat K.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Animal Production Faculty of Agriculture Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayiz M.","family":"Reda","sequence":"additional","affiliation":[{"name":"Poultry Department Faculty of Agriculture Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.21608\/ejceh.2015.253907","article-title":"The Positive effects of vitamin E and selenium with activated charcoal against aflatoxin induced oxidative stress and cytotoxic damage in rabbits","volume":"1","author":"Abdou M.","year":"2015","journal-title":"Egyptian Journal of Chemistry and Environmental Health"},{"key":"e_1_2_8_3_1","volume-title":"Official Methods of Analysis of the Association of Official Analytical Agricultural Chemists","author":"AOAC","year":"1990"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5455\/ajvs.288806"},{"key":"e_1_2_8_5_1","first-page":"288","article-title":"The biocidal effect of potassium sorbate forindoor airborne fungi remediation Desalin","volume":"57","author":"Chin Ming E. 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