{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:32Z","timestamp":1787015732624,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T00:00:00Z","timestamp":1595116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Discipline Construction Fund Project of Gansu Agricultural University","award":["GAU-XKJS-2018-053"],"award-info":[{"award-number":["GAU-XKJS-2018-053"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Previous studies have shown that the administration of melatonin (MT) to early post\u2010natal fur\u2010bearing animals increases the numbers of hair follicles (HFs). In this study, the effect of maternal MT supplementation on the HF development in offspring was investigated. To explore the potential underlying mechanisms, the expression of the melatonin receptor 1A (\n                    <jats:italic>MTNR1A<\/jats:italic>\n                    ) gene was determined in the offspring. The Rex rabbit was the animal model, and 79 same\u2010day\u2010pregnancy females were randomly assigned to either a control (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a039) or MT treatment (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a040) group, and 10\u00a0mg MT microcapsules was implanted at the base of the neck of rabbits in the treatment group. Skin, lung, liver, muscle, kidney, heart and duodenum samples were collected from the newborn rabbits. The results showed that MT improved fur quality in the offspring rabbits by reducing the diameter of primary and secondary HFs, and increasing the HF population. MT did not affect the reproductive performance of female rabbits, and it did affect the blood levels of thyroid\u2010stimulating hormone, prolactin and MT. In the offspring rabbits, MT significantly stimulated\n                    <jats:italic>MTNR1A<\/jats:italic>\n                    gene expression in the skin and heart (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.01), whereas\n                    <jats:italic>MTNR1A<\/jats:italic>\n                    gene expression was significantly suppressed in the liver and kidney (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.05). These results revealed that maternal MT supplementation increased HF density, reduced hairiness and improved the fur quality in Rex rabbit offspring. Maternal MT supply may modulate the responses of HFs in the offspring by upregulating the expression of\n                    <jats:italic>MTNR1A<\/jats:italic>\n                    in the skin. In this study, implantation of low\u2010dose MT did not affect the reproductive performance of female rabbits or on the growth of their offspring.\n                  <\/jats:p>","DOI":"10.1111\/jpn.13417","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T02:46:12Z","timestamp":1595213172000},"page":"167-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Melatonin supplement induced the hair follicle development in offspring rex rabbits"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-0898","authenticated-orcid":false,"given":"Yang","family":"Feng","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Gansu Agricultural University Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangbao","family":"Gun","sequence":"additional","affiliation":[{"name":"College of Animal 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