{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:51:04Z","timestamp":1791895864849,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002664","name":"Hunan Normal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Many countries are increasingly prohibiting the addition of antibiotics in livestock diets. Therefore, herb extracts have gradually drawn attention to substitute antibiotics. Our present study aimed to determine the effects of herbal extract mixture (HEM) in dietary on growth performance, organ weight, intestinal morphology and intestinal nutrient transporters in weaned pigs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>27 piglets (Duroc\u00a0\u00d7\u00a0[Landrace\u00a0\u00d7\u00a0Yorkshire]; Body Weight (BW)\u00a0=\u00a05.99\u00a0\u00b1\u00a00.13\u00a0kg) were weaned at day 21 and randomly divided into three groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a09 piglets\/group). All piglets received a basal diet containing similar amounts of nutrients for 14\u00a0days. The three groups were the control (no additive), the antibiotics (375\u00a0mg\/kg chlortetracycline, 20%, 500\u00a0mg\/kg enramycin, 4%, 1,500\u00a0mg\/kg oxytetracycline calcium, 50%) and the HEM group (1000\u00a0mg\/kg extract mixture of golden\u2010and\u2010silver honeysuckle, huangqi, duzhong leaves and dangshen). After 14 d of treatment, we collected tissue samples to measure organ weight, intestinal parameters, intestinal morphology, digestive enzyme activities and intestinal mRNA expression of nutrient transporters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The HEM group had no effects on growth performance and organ weight of weaned pigs. But compared with the control group, both HEM and antibiotics improved intestinal morphology, and HEM elevated the expression of nutrient transporters in ileum (SLC6A9, SLC15A1, and SLC5A1). HEM significantly decreased the activities of maltase in ileum and the ratio of small intestinal weight to BW than control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results indicate benefit effects of the supplementation of HEM in diet, including modulating intestinal morphology and increasing the mRNA expression of nutrients transporters. These findings suggest that HEM provides novel insights into a variety of herbal extract mixtures to replace antibiotics in animal production.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpn.13422","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T21:29:00Z","timestamp":1597094940000},"page":"1462-1470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effects of dietary supplementation with herbal extract mixture on growth performance, organ weight and intestinal morphology in weaning piglets"],"prefix":"10.1111","volume":"104","author":[{"given":"Meiwei","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation Hunan International Joint Laboratory of Animal Intestinal Ecology and Health School of Life Sciences Hunan Normal University 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