{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:11Z","timestamp":1787015771943,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:00:00Z","timestamp":1596844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Typhoid is a distinct gastrointestinal disease that largely affects the public by consumption of inadequately or partially cooked eggs from contaminated laying hen farms. This has led the research on laying hens to focus on controlling the contamination by an effective anti\u2010\n                    <jats:italic>Salmonella<\/jats:italic>\n                    spp. agent in the intestine. The treatments included, control, without challenge; PC,\n                    <jats:italic>Salmonella typhimurium<\/jats:italic>\n                    challenged (STC); BP5, 5\u00a0ppm bacteriophage\/kg\u00a0+\u00a0STC; BP10, 10\u00a0ppm bacteriophage\/kg\u00a0+\u00a0STC, on\n                    <jats:italic>Salmonella<\/jats:italic>\n                    shedding, body organs inflammatory reactions, and expression of toll\u2010like receptor (TLR), pro\u2010inflammatory cytokines, and heat shock protein (HSP) in the jejunum, liver,and thigh muscle in the STC laying hens. The RT\u2010PCR method was used to enumerate the number of\n                    <jats:italic>Salmonella typhimurium<\/jats:italic>\n                    in the organs. The birds in the STC groups exhibited the increased population of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    spp. in the excreta (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.01). In the STC groups, the BP5 and BP10 laying hens exhibited a lower (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.01) population of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    spp. in the excreta at d 7 after STC. Supplementation of bacteriophage significantly decreased (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.01) the colonization of\n                    <jats:italic>S. Typhimurium<\/jats:italic>\n                    in the spleen, oviduct, caecum and excreta. Among the STC treatments, the BP10 laying hens showed lower (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.01) mRNA expression of interferon\u2010\u03b3 (IFN\u03b3) and TLR\u20104 in the jejunum compared with the PC treatment. After the STC, dietary supplementation with BP5 or BP10 decreased (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.01) the mRNA expressions of IFN\u03b3, HSP\u201027 and tumour necrosis factor\u2010\u03b1 in the liver compared with the PC treatment. These results suggest that bacteriophage can be used as an effective agent to decrease\n                    <jats:italic>S. Typhimurium<\/jats:italic>\n                    contamination in laying hens and possibly lower\n                    <jats:italic>S. Typhimurium<\/jats:italic>\n                    transfer to foods.\n                  <\/jats:p>","DOI":"10.1111\/jpn.13424","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T01:43:20Z","timestamp":1596937400000},"page":"952-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of an anti\u2010\n                    <i>Salmonella. Typhimurium<\/i>\n                    Bacteriophage on intestinal microbiota and immunity status of laying hens"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6093-4812","authenticated-orcid":false,"given":"MiJin","family":"Lee","sequence":"first","affiliation":[{"name":"Poultry Science Division Livestock Research Development National Institute of Animal Science RDA  Cheonan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9191-0613","authenticated-orcid":false,"given":"Abdolreza","family":"Hosseindoust","sequence":"additional","affiliation":[{"name":"College of Animal Life Sciences Kangwon National University  Chuncheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8848-8028","authenticated-orcid":false,"given":"SeungMin","family":"Oh","sequence":"additional","affiliation":[{"name":"Gyeongsangbuk\u2010do Livestock Research Institute  Yeongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-2761","authenticated-orcid":false,"given":"HanSeo","family":"Ko","sequence":"additional","affiliation":[{"name":"College of Animal Life Sciences Kangwon National University  Chuncheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5223-099X","authenticated-orcid":false,"given":"EunSeok","family":"Cho","sequence":"additional","affiliation":[{"name":"Poultry Science Division Livestock Research Development National Institute of Animal Science RDA  Cheonan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2634-5109","authenticated-orcid":false,"given":"SooJin","family":"Sa","sequence":"additional","affiliation":[{"name":"Poultry Science Division Livestock Research Development National Institute of Animal Science RDA  Cheonan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6821-6084","authenticated-orcid":false,"given":"YoungIn","family":"Kim","sequence":"additional","affiliation":[{"name":"CTC Bio, Inc.  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-5037","authenticated-orcid":false,"given":"JungWoo","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Animal Life Sciences Kangwon National University  Chuncheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9518-7917","authenticated-orcid":false,"given":"JinSoo","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Animal Life Sciences Kangwon National University  Chuncheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pex109"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12204"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2611"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.07.088"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12358"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6941.2006.00190.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/01445340500112157"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12567"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.17221\/7\/2016-VETMED"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535593"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731116001166"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2003.08.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(96)00048-8"},{"issue":"2","key":"e_1_2_8_15_1","first-page":"e05596","article-title":"Salmonella control in poultry flocks and its public health impact","volume":"17","author":"Koutsoumanis K.","year":"2019","journal-title":"EFSA Journal"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/1828051X.2016.1188676"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2016.08.003"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.09.012"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04624.x"},{"key":"e_1_2_8_20_1","first-page":"1","article-title":"Adiposity and proinflammatory state: The chicken or the egg","volume":"1","author":"Moreno\u2010Aliaga M. J.","year":"2005","journal-title":"Adipocytes"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13112"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4081\/ijas.2015.3452"},{"key":"e_1_2_8_23_1","volume-title":"Nutrient requirement of poultry","author":"NRC","year":"1994"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13070"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12248"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2001.tb10500.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0307.12202"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1810"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2016.04.002"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-146"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12895"}],"container-title":["Journal of Animal Physiology and Animal Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpn.13424","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpn.13424","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpn.13424","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpn.13424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T13:19:24Z","timestamp":1693315164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpn.13424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,8]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/jpn.13424"],"URL":"https:\/\/doi.org\/10.1111\/jpn.13424","archive":["Portico"],"relation":{},"ISSN":["0931-2439","1439-0396"],"issn-type":[{"value":"0931-2439","type":"print"},{"value":"1439-0396","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,8]]},"assertion":[{"value":"2020-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}