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A total of 48 Duroc\u00a0\u00d7\u00a0Landrace\u00a0\u00d7\u00a0Yorkshire cross\u2010bred growing pigs (73\u00a0\u00b1\u00a02\u00a0days of age; 24.37\u00a0\u00b1\u00a02.86\u00a0kg) were allocated to four groups randomly, each group consisting of six pens with two pigs each. The pigs were fed a control diet (CON), a diet containing 2% wheat bran fibre (WB), a diet containing 2% inulin (IN), and a diet containing both of 1% wheat bran fibre and 1% inulin (MIX), respectively. The trial lasted for 28\u00a0days. The results showed that MIX fed pigs had a higher percentage of fat in the liver than those fed the CON (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). IN, WB or MIX feeding decreased the concentrations of acetate and total SCFAs in colon compared with CON (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). Feeding WB or IN also decreased the colonic butyrate concentrations compared with CON (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). However, the serum level of valeric acid was elevated in the IN, WB and MIX group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). MIX fed pigs tended to have lower levels of propionate in serum than the WB fed pigs (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.098). MIX feeding enhanced the mRNA expression of lipid synthesis\u2010related genes in liver compared with CON (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Feeding IN decreased the expression of bile acids synthesis\u2010related genes in liver and increased mRNA expression of SCFAs transporter <jats:italic>SLC16A1<\/jats:italic> in colon compared with CON (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). In this study, these data indicated that the combined supplementation of wheat bran fibre and inulin decreased the SCFAs concentrations in the colon, enhanced the genes <jats:italic>FAS<\/jats:italic> and <jats:italic>HNF\u20104\u03b1<\/jats:italic> mRNA expression in liver and induced liver lipid accumulation in growing pigs.<\/jats:p>","DOI":"10.1111\/jpn.13429","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T06:19:25Z","timestamp":1596349165000},"page":"1484-1493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of dietary fibres on gut microbial metabolites and liver lipid metabolism in growing pigs"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7871-1916","authenticated-orcid":false,"given":"Yaolian","family":"Hu","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Disease\u2010Resistant Nutrition Ministry of 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