{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:27:47Z","timestamp":1788967667404,"version":"build-2803163510"},"reference-count":69,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Homeostasis of calcium (Ca) and phosphate (P<jats:sub>i<\/jats:sub>) is maintained by a concerted interplay of absorption and reabsorption via the gastrointestinal tract and the kidney and by storage and mobilization from the bone regulated mainly by parathyroid hormone (PTH), 1,25\u2010dihydroxycholecalciferol and calcitonin. The present study aimed at characterizing the effects of dietary P restriction on bone, vitamin D metabolism and rumen fermentation traits reflecting the endogenous P cycle maintaining the ruminal P supply for microbial metabolism. The experiments were done in eleven female, non\u2010pregnant, non\u2010lactating four\u2010 to nine\u2010year\u2010old Black Headed Mutton sheep allotted to two feeding groups: \"P\u2010restricted\" (0.11% P\/kg DM and 0.88% Ca\/kg DM) and \"Control\" (0.38% P\/kg DM and 0.88% Ca\/kg DM). Dietary P restriction did not lead to hypophosphataemia, probably due to a compensation by bone mobilization, demonstrated by increased serum concentrations of a resorption marker and altered gene expression in bone tissue. In addition, the RNA expression of fibroblast growth factor 23, a bone\u2010derived factor involved in the regulation of vitamin D metabolism, was significantly reduced with dietary P restriction. Furthermore, several genes related to vitamin D metabolism and plasma concentrations of 1,25\u2010(OH)<jats:sub>2<\/jats:sub>D were associated with serum concentrations of phosphate (P<jats:sub>i<\/jats:sub>). In the parotid gland, the expression of the P<jats:sub>i<\/jats:sub> transporter NaPi2b was negatively associated with serum P<jats:sub>i<\/jats:sub> and positively with parathyroid PTH expression. Although P<jats:sub>i<\/jats:sub> concentrations in saliva and the gastrointestinal tract were significantly reduced, we found no adverse effects of the P\u2010restricted ration on the production of short chain fatty acids, but slight differences in the production of butyrate as well as its relationship to rumen P<jats:sub>i<\/jats:sub> and ammonia concentrations that might indicate an impact on ruminal fermentation.<\/jats:p>","DOI":"10.1111\/jpn.13449","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T14:57:36Z","timestamp":1601564256000},"page":"35-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Dietary phosphorus restriction affects bone metabolism, vitamin D metabolism and rumen fermentation traits in sheep"],"prefix":"10.1111","volume":"105","author":[{"given":"Oriana M.","family":"K\u00f6hler","sequence":"first","affiliation":[{"name":"Department of Animal Sciences Faculty of Agricultural Sciences University of Goettingen Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Gr\u00fcnberg","sequence":"additional","affiliation":[{"name":"Clinic for Cattle University of Veterinary Medicine Hannover, Foundation Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Schnepel","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Cell Biology University of Veterinary Medicine Hannover, Foundation Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra S.","family":"Muscher\u2010Banse","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Cell Biology University of Veterinary Medicine Hannover, Foundation Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Rajaeerad","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences College of Agriculture Isfahan University of Technology Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-7745","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Hummel","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences Faculty of Agricultural Sciences University of Goettingen Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Breves","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Cell Biology University of Veterinary Medicine Hannover, Foundation Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1734-5024","authenticated-orcid":false,"given":"Mirja R.","family":"Wilkens","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences Faculty of Agricultural Sciences University of Goettingen Goettingen Germany"},{"name":"Institute of Physiology and Cell Biology University of Veterinary Medicine Hannover, Foundation Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1071\/AN17363"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00010-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1046"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.051308.111339"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1079\/NRR19910011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v028a19"},{"issue":"2","key":"e_1_2_9_8_1","first-page":"475","article-title":"Dietary phosphorus for beef cows","volume":"47","author":"Call J. 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