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Thirty\u2010six Holstein bulls (age, 17.0\u00a0\u00b1\u00a00.49\u00a0months; body weight, 493.3\u00a0\u00b1\u00a039.7\u00a0kg) were randomly allocated to three dietary treatments. The metabolizable energy of diets was 10.12, 10.90 and 11.68\u00a0MJ\/kg. Bulls in each dietary treatment were sampled at the age of 20, 23 or 26\u00a0months. Results showed that serum glutathione peroxidase and superoxide dismutase decreased with the increasing age. Dietary energy and age had interaction effects on the expressions of fatty acid synthase, peroxisome proliferator\u2010activated receptor alpha, acyl coenzyme A oxidase 1 and carnitine palmitoyl\u2010transferase 1 alpha. Besides, the increase of age and dietary energy increased the expression of liver phosphoenolpyruvate carboxykinase 1. The expressions of liver glucose\u20106\u2010phosphatase, tumour necrosis factor alpha and sterol regulatory element binding protein 1 increased with the increasing age. The increase of age and dietary energy increased the proportions of C18:1<jats:italic>cis<\/jats:italic>\u20109, C18:2n\u20106<jats:italic>trans<\/jats:italic> and monounsaturated fatty acid. In summary, the increase of age and dietary energy enhanced the intensity of metabolic changes and inflammatory responses. Dietary energy and age affected the expressions of liver lipid metabolism\u2010related genes, further affected meat fatty acid composition of Holstein bulls.<\/jats:p>","DOI":"10.1111\/jpn.13457","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T06:05:05Z","timestamp":1601618705000},"page":"199-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of dietary energy on antioxidant capacity, glucose\u2013lipid metabolism and meat fatty acid profile of Holstein bulls at different ages"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6950-5117","authenticated-orcid":false,"given":"Haibo","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University  Beijing China"},{"name":"Key Laboratory of Qinghai\u2010Tibetan Plateau Animal Genetic Resource Reservation and Utilization (Southwest Minzu University) Ministry of Education  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-2040","authenticated-orcid":false,"given":"Wenjing","family":"Niu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhantao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Animal Science University of Tennessee  Knoxville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghai","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12365"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19960010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/684159"},{"key":"e_1_2_9_5_1","first-page":"211","article-title":"Metabolism of fatty acids in tissues and organs of the ruminants\u2010a review","volume":"34","author":"Brzozowska A. 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