{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:23:40Z","timestamp":1791919420624,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fifty\u2010six piglets were weaned at 21\u00a0days and randomly assigned to 1 of 8 dietary treatments with 7 replicate pens for a 14\u2010day experimental period. The eight experimental diets were prepared via a 2\u00a0\u00d7\u00a04 factorial arrangement with citric acid (CA; 0 and 0.3%) and dietary electrolyte balance (dEB, Na +K \u2212 Cl mEq\/kg of the diet; \u221250, 100, 250, and 400\u00a0mEq\/kg). Varying dEB values were obtained by altering calcium chloride and sodium bicarbonate contents. Dietary CA significantly increased (<jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>.05) villus height (VH) and villus height:crypt depth (VH:CD) in the jejunum. Piglets fed a 250\u00a0mEq\/kg diet increased (<jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>.05) VH and VH:CD values in the duodenum. Jejunal VH and VH:CD increased (quadratic; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), and ileal VH:CD (liner and quadratic; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) decreased as dEB was increased in diets without CA, but no such effect was observed on the diets containing CA (dEB \u00d7CA; <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>.05). The CD in jejunum (quadratic; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) increased as dEB was increased in diets containing CA, whereas it was decreased (linear; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) in the diets without CA (dEB \u00d7CA; <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>.001). Dietary CA increased maltase activity and reduced the number of Ki67\u2010positive cells (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Increasing dEB values in diets without CA increased sucrose and lactase activities (quadratic; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), but no such effect was observed in the diets with CA (dEB \u00d7CA; <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>.05). An interaction effect between dEB and CA on the number of Ki67\u2010positive cells was observed (<jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>.001). In conclusion, 250\u00a0mEq\/kg dEB diet with CA improved piglet intestinal digestion and absorption function by improving intestinal morphology and increasing digestive enzyme activities. However, these improvements were also observed in piglets fed the 100\u00a0mEq\/kg dEB diet without CA.<\/jats:p>","DOI":"10.1111\/jpn.13491","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T05:48:22Z","timestamp":1609912102000},"page":"272-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects and interaction of dietary electrolyte balance and citric acid on growth performance, intestinal histomorphology, digestive enzyme activity and nutrient transporters expression of weaned piglets"],"prefix":"10.1111","volume":"105","author":[{"given":"Qingqing","family":"Deng","sequence":"first","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human Health College of Life Sciences Hunan Normal University Changsha 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College of Life Sciences Hunan Normal University Changsha China"},{"name":"Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South\u2010Central Ministry of Agriculture Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production Key Laboratory of Agro\u2010ecological Processes in Subtropical Region Institute of Subtropical Agriculture Chinese Academy of Sciences Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Yin","sequence":"additional","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human Health College of Life Sciences Hunan Normal University Changsha China"},{"name":"Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process Scientific Observing and Experimental Station 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