{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:23:02Z","timestamp":1770276182908,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T00:00:00Z","timestamp":1616803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The main objective of this study was to determine which biochemical blood parameters can serve as indicators of Zn or Zn\/Cd burden and tapeworm infection. This study was performed on 44 Wistar male rats during a 6\u2010week period, when rats were or were not fed a zinc\/cadmium rich diet and were or were not infected with tapeworms (<jats:italic>Hymenolepis diminuta<\/jats:italic>). Total protein, albumin, urea, glucose, triacylglycerols, non\u2010esterified fatty acids, cholesterol, alkaline phosphatase, aspartate aminotransferase, uric acid, Mg, Ca, P and Zn levels were analysed. Control rats with tapeworm infection had significantly higher (<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.05) total protein, urea and phosphorus concentrations than did rats unaffected by any experimental factor. Rats given overdoses of zinc lactate exhibited significantly lower glucose level<jats:styled-content>s<\/jats:styled-content> than did the other rats, especially those infected with tapeworms. Low glucose level in uninfected rats indicate a Zn overdose; high doses of zinc lactate likely decrease levels of glucose via cortisol, which is released during stress. Rats fed the Zn\/Cd hyperaccumulating plant <jats:italic>Arabidopsis halleri<\/jats:italic> and infected with tapeworms had significantly higher (<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.01) cholesterol and urea levels but lower zinc, triacylglycerol, and alkaline phosphatase levels than did rats fed the same diet but free of tapeworms. The increase of alkaline phosphatase level in uninfected rats may indicate both Zn\/Cd burden and rat liver damage. Overall, this study not only supports the theory that <jats:italic>H<\/jats:italic>.<jats:italic>\u00a0diminuta<\/jats:italic> can serve as a promising model for helminth therapy of the host mammal but also confirmed that this tapeworm is capable to protect somehow the host organism from the harmful effects of heavy metals.<\/jats:p>","DOI":"10.1111\/jpn.13524","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T07:59:34Z","timestamp":1616831974000},"page":"989-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of excessive dietary zinc or zinc\/cadmium and tapeworm infection on the biochemical parameters in rats"],"prefix":"10.1111","volume":"105","author":[{"given":"Vladislav","family":"Sloup","sequence":"first","affiliation":[{"name":"Department of Zoology and Fisheries Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8266-190X","authenticated-orcid":false,"given":"Ivana","family":"Jankovsk\u00e1","sequence":"additional","affiliation":[{"name":"Department of Zoology and Fisheries Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"\u0160tolcov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Magd\u00e1lek","sequence":"additional","affiliation":[{"name":"Department of Zoology and Fisheries Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Kare\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Zoology and Fisheries Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylva","family":"Lankov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Zoology and Fisheries Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iva","family":"Langrov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Zoology and Fisheries Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2298\/AVB1306581D"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128775"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-017-1008-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-016-7123-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2478\/sab-2018-0015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-0787-3"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182018000896"},{"key":"e_1_2_10_9_1","volume-title":"Alkaline phosphatase","author":"Kaslow J. 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