{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:35:33Z","timestamp":1789727733658,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2021,9]]},"abstract":"Abstract<\/jats:title>The effect of Illicium verum<\/jats:italic> extracts (IVE) or Eucommia ulmoides leaf<\/jats:italic> extracts (ELE) on nutrient availability, duodenal and jejunal antioxidant ability of Duroc \u00d7Landrace \u00d7 Yorkshire (DLY) and Chinese native Licha\u2010black (LCB) piglets was investigated. Ninety\u2010six piglets (48 DLY and 48 LCB respectively) without significant difference in body weight (11.22\u00a0\u00b1\u00a00.32\u00a0kg) were used in a 2\u00a0\u00d7\u00a04 factorial design. Animals were randomly allocated to four treatments, and each had four replicates with three DLY and three LCB piglets. Treatments were basal diet (CON) and basal diet with 500\u00a0mg\/kg IVE, 250\u00a0mg\/kg ELE and 50\u00a0mg\/kg chlortetracycline (CHL) respectively. Animals were placed individually for 7\u2010days adaptation following 42\u2010days test. Results showed the significant interaction (p<\/jats:italic>\u00a0<\u00a00.05) between dietary treatments and pig species in activity of total superoxide dismutase (T\u2010SOD) and glutathione peroxidase (GSH\u2010Px), content of malondialdehyde (MDA), and \u03b1\u2010tumour necrosis factor (TNF<\/jats:italic>\u2010\u03b1<\/jats:italic>), nuclear factor erythroid 2\u2010related factor 2 (Nrf2<\/jats:italic>) and Nrf2<\/jats:italic>\/TNF<\/jats:italic>\u2010\u03b1<\/jats:italic> at mRNA and protein level in duodenum and jejunum of DLY and LCB piglets. The IVE and ELE increased (p<\/jats:italic>\u00a0<\u00a00.05) activity of GSH\u2010Px and T\u2010SOD, and the Nrf2<\/jats:italic>\/TNF<\/jats:italic>\u2010\u03b1<\/jats:italic> at mRNA and protein level, however, the decreased (p<\/jats:italic>\u00a0<\u00a00.05) MDA content, and TNF<\/jats:italic>\u2010\u03b1<\/jats:italic> at mRNA and protein level in duodenum and jejunum were observed. The CHL decreased (p<\/jats:italic>\u00a0<\u00a00.05) activity of GSH\u2010Px and T\u2010SOD, TNF<\/jats:italic>\u2010\u03b1<\/jats:italic> and Nrf2<\/jats:italic> at mRNA and protein level in duodenum, but increased (p<\/jats:italic>\u00a0<\u00a00.05) MDA content and Nrf2<\/jats:italic>\/TNF<\/jats:italic>\u2010\u03b1<\/jats:italic> in jejunum. DLY piglets had higher (p<\/jats:italic>\u00a0<\u00a00.05) nutrient digestibility (organic matter, crude protein and gross energy), availability (biological value and net protein utilization), MDA content, and TNF<\/jats:italic>\u2010\u03b1<\/jats:italic> at mRNA and protein level in jejunum, and had lower (p<\/jats:italic>\u00a0<\u00a00.05) activity of GSH\u2010Px and T\u2010SOD, and Nrf2<\/jats:italic> and Nrf2<\/jats:italic>\/TNF<\/jats:italic>\u2010\u03b1<\/jats:italic> at mRNA and protein level in duodenum and jejunum than LCB. In conclusion, the 500\u00a0mg\/kg IVE and 250\u00a0mg\/kg ELE improved the nutrient availability, and the improvement of antioxidant capacity is realized by activating the Nrf2<\/jats:italic>\/TNF<\/jats:italic>\u2010\u03b1<\/jats:italic> of duodenum and jejunum. The CHL had adverse effects on antioxidant ability of DLY and LCB piglets. The results showed that the nutrient digestion and absorption capacity of DLY were stronger than that of LCB piglets, but the antioxidant capacity was lower than that of LCB piglets. Therefore, the IVE and ELE are recommended as a new potential alternative to antibiotics in piglets\u2019 diets.<\/jats:p>","DOI":"10.1111\/jpn.13534","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T11:28:43Z","timestamp":1616758123000},"page":"916-926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Illicium verum<\/i> and Eucommia ulmoides<\/i> leaf extracts promote nutrient availability and antioxidant capacity in piglets by upregulating duodenal and jejunal Nrf2\/TNF\u2010<\/i>\u03b1<\/i>"],"prefix":"10.1111","volume":"105","author":[{"given":"Wenshuang","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Animal Sciences and Technology Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention Shandong Agricultural University Taian City Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6455-1894","authenticated-orcid":false,"given":"Shanshan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jiaozhou Animal Husbandry and Veterinary Service Center Jiaozhou, Qingdao City Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaibin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences and Technology Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention Shandong Agricultural University Taian City Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiren","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences and Technology Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention Shandong Agricultural University Taian City Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences and Technology Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention Shandong Agricultural University Taian City Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faxiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences and Technology Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention Shandong Agricultural University Taian City Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences and Technology Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention Shandong Agricultural University Taian City Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinshan","family":"Ge","sequence":"additional","affiliation":[{"name":"Shandong Zhongcheng Feed Technology Co., Ltd Feicheng City Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Wang","sequence":"additional","affiliation":[{"name":"Lethbridge Research and Development Centre Agriculture and Agri\u2010Food Canada Lethbridge Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences and Technology Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention Shandong Agricultural University Taian City Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030800"},{"key":"e_1_2_10_3_1","first-page":"15","article-title":"Effect of Chinese star anise (Illicium verum Hook. f) on the blood biochemical parameters and antioxidant status in the serum and tissues of broiler chickens","volume":"27","author":"Alhajj M. 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