{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:13:50Z","timestamp":1781223230160,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to assess the effects of dietary humate substances (HS) and CloSTAT (<jats:italic>Bacillus subtilis<\/jats:italic> PB6) on the thyroid activity and histology, iron profile, blood haematology and performance of growing Japanese quail. A total of 216 unsexed 7\u2010day\u2010old quail chicks were randomly assigned to six groups. The first group was fed a basal diet (BD) without any additives (control); the 2nd group received BD plus 0.05% CloSTAT, the 3rd and 4th groups were given BD plus 0.4% and 0.8% HS, respectively; and the 5th and 6th groups were administered BD plus CloSTAT\u00a0+\u00a00.4% HS and BD plus CloSTAT\u00a0+\u00a00.8% HS, respectively. The results showed that the growth performance was improved with the addition of CloSTAT alone or in combination with 0.4% HS compared with the control. Haematological parameters, iron level and transferrin saturation % were significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) increased by feeding HS compared with the control group. Serum thyroxin and triiodothyronine levels were significantly (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) increased by adding CloSTAT relative to the control. Supplementation of 0.8% HS caused deterioration in histomorphometry parameters of the thyroid gland, but these parameters were improved in response to CloSTAT compared with the control. In conclusion, dietary <jats:italic>B.\u00a0subtilis<\/jats:italic> PB6 as CloSTAT or CloSTAT\u00a0+\u00a00.4% HS supplementation may be efficacious in enhancing the growth performance and boosting the thyroid activity of growing Japanese quail. Moreover, the addition of 0.4% or 0.8% HS to quail diets boosted their iron profile and haematological parameters.<\/jats:p>","DOI":"10.1111\/jpn.13543","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T11:42:29Z","timestamp":1616672549000},"page":"110-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Impact of humate substances and <i>Bacillus subtilis<\/i> PB6 on thyroid activity and histomorphometry, iron profile and blood haematology of quail"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4430-1492","authenticated-orcid":false,"given":"Shaaban S.","family":"Elnesr","sequence":"first","affiliation":[{"name":"Department of Poultry Production Faculty of Agriculture Fayoum University  Fayoum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel\u2010Razik H.","family":"Abdel\u2010Razik","sequence":"additional","affiliation":[{"name":"Department of Histology Faculty of Veterinary Medicine Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4497-1322","authenticated-orcid":false,"given":"Hamada A. M.","family":"Elwan","sequence":"additional","affiliation":[{"name":"Animal and Poultry Production Department Faculty of Agriculture Minia University  El\u2010Minya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-019-02055-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v15i3.5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2014.10.012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.12-0368"},{"issue":"3","key":"e_1_2_8_6_1","first-page":"167","article-title":"Humic acid as a feed additive in poultry diets: A review","volume":"20","author":"Arif M.","year":"2019","journal-title":"Iranian Journal of Veterinary 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