{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:49:01Z","timestamp":1790394541771,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T00:00:00Z","timestamp":1631404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early\u2010life diseases in dairy animals are main causes of economic loss in livestock production. Oxidative stress (OS) and thyroid hormones are important inter\u2010related components in the normal physiology of this critical period of life. However, limited information regarding their physiology in goat kids is available. This study was conducted to investigate the age\u2010related changes of thyroid hormones, some serum oxidative biomarkers and trace elements in healthy Saanen goat kids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen newborn healthy Saanen goat kids (14 females and five males) were studied longitudinally from birth until three months of age. Blood sampling was performed 24\u201348\u00a0h after birth and was repeated on 10\u00a0\u00b1\u00a02, 28\u00a0\u00b1\u00a02, 56\u00a0\u00b1\u00a02 and 84\u00a0\u00b1\u00a02\u00a0days of age. The serum levels of thyroid hormones, malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant capacity (TAC), selenium (Se), manganese (Mn) and molybdenum (Mo) were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age\u2010related changes were observed for all measured variables except for MDA (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). A decreasing trend was detected throughout the study in thyroid hormones, T3: T4 ratio and Mn (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). Some factors decreased from birth to day 10 (Se) or day 28 (TAC and GSH) and followed by an increasing trend that extended to day 84 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). There were significant correlations between thyroid hormones and TAC, as well as Mn levels (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results imply that specific age\u2010related reference values are essential for proper interpretation of the serum level of thyroid hormones and Mn in Saanen goat kids during the first three months of life. In addition, given the high level of thyroid hormones particularly during the first days of life, and their relationship with oxidative biomarkers and trace elements, improving the antioxidant system in this critical period is essential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpn.13634","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T18:15:06Z","timestamp":1631470506000},"page":"494-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Age\u2010related changes in thyroid hormones, some serum oxidative biomarkers and trace elements and their relationships in healthy Saanen goat kids during the first three month of age"],"prefix":"10.1111","volume":"106","author":[{"given":"Elham","family":"Valavi","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Faculty of Veterinary Medicine Ferdowsi University of Mashhad  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4226-8393","authenticated-orcid":false,"given":"Mahdieh","family":"Zaeemi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Faculty of Veterinary Medicine Ferdowsi University of Mashhad  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Mohri","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Faculty of Veterinary Medicine Ferdowsi University of Mashhad  Mashhad Iran"},{"name":"Faculty of Veterinary Medicine Center of Excellence in Ruminant Abortion and Neonatal Mortality Ferdowsi University of Mashhad  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,12]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"209","article-title":"Copper, manganese, zinc, iron and calcium in fetal tissue of Baladi goats at northern of Jordan","volume":"2","author":"Abdelrahman M. 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