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Four\u2010week\u2010old New Zealand White rabbits (<jats:italic>n\u00a0<\/jats:italic>=\u00a096) with an initial body weight of 0.750 \u00b1 0.23\u00a0g were randomly divided into four groups (<jats:italic>n\u00a0<\/jats:italic>=\u00a024). One group was the control received only corn oil orally, while group L were received lindane daily via gavage in corn oil (4\u00a0mg\/kg BW; 1\/50 LD<jats:sub>50<\/jats:sub> for oral dose), group GS was treated with 50\u00a0g grape seed \/kg diet, and group LGS treated with a combination of both L and GS for 98\u00a0days. Results revealed that final body weight (FBW), average daily gain (ADG), dry matter intake and feed efficiency (FE) were similar between GS and control groups, and achieved the highest FBW and ADG, and the best FE. Caecum pH of the L group increased, while the caecum pH of the GS group decreased sharply. There was a significant increase in the concentration of total VFA, acetic acid, propionic acid and NH<jats:sub>3<\/jats:sub>\u2010N in the GS group, but butyric acid level decreased. GS treatment resulted in a significant increase in the concentrations of total protein, albumin and AChE. GPx, GST, CAT and SOD activity decreased, but TBARS activity significantly increased in the group L, while GS caused a significant elevation of antioxidant activity in the liver. These results confirm that the antioxidant compounds present in grape seed can alleviate the oxidative stress caused by lindane\u2010induced hepatotoxicity and could be a useful supplement to maintain health and improve performance in rabbits.<\/jats:p>","DOI":"10.1111\/jpn.13685","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T05:39:59Z","timestamp":1643348399000},"page":"899-909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Grape seed alleviates lindane\u2010induced oxidative stress and improves growth performance, caecal fermentation and antioxidant capacity in growing rabbits"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5873-7986","authenticated-orcid":false,"given":"Salma H.","family":"Abu Hafsa","sequence":"first","affiliation":[{"name":"Livestock Research Department Arid Lands Cultivation Research Institute City of Scientific Research and Technological Applications  New Borg El\u2010Arab, Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7895-3109","authenticated-orcid":false,"given":"Ayman A.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Animal Production Research Institute Agriculture Research Center  Dokki, Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"17","article-title":"Grape seed (vitis vinifera l.) 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