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Thirty\u2010two ([Landrace\u00a0\u00d7\u00a0Yorkshire]\u00a0\u00d7\u00a0Duroc) piglets, weaned at 25\u00a0days of age, were randomly assigned into four groups. Group I was fed the basal diet. Group II were fed a basal diet supplemented with 2\u00a0g\/kg IMO for 14 consecutive days and then 4\u00a0g\/kg IMO for another 14\u00a0days. Group III were fed diet with 0.5\u00a0g\/kg CHE for 14\u00a0days and 1\u00a0g\/kg CHE for another 14\u00a0days. Group IV were fed diet with (2\u00a0g\/kg IMO\u00a0+\u00a00.5\u00a0g\/kg CHE) for 14\u00a0days and (4\u00a0g\/kg IMO\u00a0+1\u00a0g\/kg CHE) for another 14\u00a0days. Results showed that diets supplemented with IMO, CHE or their combination did not influence the diarrhoea rate and intestinal morphology, while co\u2010administration of IMO with CHE tended to have higher average daily gain. Serum biochemical analysis showed that dietary CHE decreased aspartate aminotransferase levels, while inclusion of IMO led to a decrease in high\u2010density lipoprotein. Moreover, co\u2010administration of IMO with CHE significantly upregulated the expression of TGF\u2010\u03b2, a potent anti\u2010inflammatory cytokine, in jejunal mucosa of piglets. Further, CHE significantly increased the abundance of <jats:italic>Bifidobacterium<\/jats:italic> in ileal digesta. Meanwhile, the combination of IMO and CHE significantly increased <jats:italic>Bifidobacterium<\/jats:italic> in the caecum of piglets. Additionally, dietary IMO, CHE or their combination significantly reduced the number of potential entero\u2010pathogen <jats:italic>Escherichia coli<\/jats:italic> in ileal contents and <jats:italic>Clostridium<\/jats:italic> species in caecal digesta. These results indicated that application of IMO or CHE could favourably modulate the intestinal microbial composition of piglets, while their beneficial impact and molecular mechanism on intestinal health warrants further investigation.<\/jats:p>","DOI":"10.1111\/jpn.13687","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T04:48:21Z","timestamp":1643345301000},"page":"671-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of isomalto\u2010oligosaccharides and herbal extracts on growth performance, serum biochemical profiles and intestinal bacterial populations in early\u2010weaned piglets"],"prefix":"10.1111","volume":"106","author":[{"given":"Guolin","family":"Pi","sequence":"first","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation College of Life Sciences Hunan Normal University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junmin","family":"Wang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation College of Life Sciences Hunan Normal University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxin","family":"Song","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation College of Life Sciences Hunan Normal University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9953-4755","authenticated-orcid":false,"given":"Yali","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation College of Life Sciences Hunan Normal University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1164-5771","authenticated-orcid":false,"given":"Huansheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation College of Life Sciences Hunan Normal University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109252"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2527\/2003.81123035x"},{"key":"e_1_2_10_4_1","first-page":"181","article-title":"Herbal extracts and organic acids as natural feed additives in pig diets","volume":"43","author":"Costa L. 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