{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:24:48Z","timestamp":1790886288506,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T00:00:00Z","timestamp":1646438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Licorice flavonoids, a bioactive substance derived from glycyrrhiza, have been reported for many pharmacological properties and are beneficial to animal health. This study aimed to explore the effects of licorice flavonoids powder (LFP) on growth performance and intestinal health of piglets. A total of 96 weaned piglets were randomly assigned into four treatments and supplemented with 0, 50, 150 and 250\u2009mg\/kg LFP for 5\u2009weeks. Dietary LFP supplementation tended to increase (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.068) average daily gain (ADG) and reduce (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.089) the feed intake\/body gain (F\/G) of piglets than that of the control group during 15\u201335\u2009days; and concentrations of LFP supplementation reduced (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) diarrhoea index during 14\u201335\u2009days and 0\u201335\u2009days. Piglets fed on diets supplied with LFP had a lower (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) pH in caecum and colon. Dietary LFP supplementation increased (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) the villi height and the ratio of villi height\/crypt depth in duodenum, and reduced (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) crypt depth in duodenum. Compared with the control group, 250\u2009mg\/kg LFP supplementation up\u2010regulated (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) the mRNA level of\n                    <jats:italic>occludin<\/jats:italic>\n                    (\n                    <jats:italic>OCLN<\/jats:italic>\n                    ) in ileum. Meanwhile, dietary LFP supplementation down\u2010regulated (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) mRNA abundance of\n                    <jats:italic>Interleukin<\/jats:italic>\n                    (\n                    <jats:italic>IL<\/jats:italic>\n                    )\n                    <jats:italic>\u20101\u03b2, IL\u20108<\/jats:italic>\n                    and\n                    <jats:italic>induced nitrogen monoxide synthase<\/jats:italic>\n                    (\n                    <jats:italic>INOS<\/jats:italic>\n                    ) in duodenum. Dietary 150\u2009mg\/kg LFP supplementation down\u2010regulated (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) mRNA abundance of\n                    <jats:italic>IL\u20101\u03b2<\/jats:italic>\n                    and 250\u2009mg\/kg LFP up\u2010regulated (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) the expression of\n                    <jats:italic>IL\u201010<\/jats:italic>\n                    in ileum. In summary, dietary LFP supplementation has a trend to improve the performance of weaning piglets, those improvements are accompanied by reduction in diarrhoea, enhancement of intestinal morphological structure, barrier function, immune function, and development. In general, 150\u2009mg\/kg LFP supplementation is more effective.\n                  <\/jats:p>","DOI":"10.1111\/jpn.13694","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T13:53:03Z","timestamp":1646488383000},"page":"147-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effect of dietary licorice flavonoids powder on performance, intestinal immunity and health of weaned piglets"],"prefix":"10.1111","volume":"107","author":[{"given":"Ting","family":"You","sequence":"first","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010resistant Nutrition Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayong","family":"Tang","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010resistant Nutrition Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenggang","family":"Yin","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010resistant Nutrition Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Jia","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University Chengdu China"},{"name":"Key Laboratory of Animal Disease\u2010resistant Nutrition Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-7528","authenticated-orcid":false,"given":"Guangmang","family":"Liu","sequence":"additional","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University Chengdu China"},{"name":"Key Laboratory of Animal 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