{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:48:41Z","timestamp":1777456121301,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Situations in which cattle are feed\u2010deprived over extensive periods of time are common in the context of transport and is an animal welfare concern which may also compromise growth and carcass yield grade. This study investigated how the main components of an oral rehydration solution would affect BW loss and blood parameters in feed\u2010deprived bulls. Three dose\u2013response experiments were performed with 24 bulls each (<jats:italic>n<\/jats:italic>\u2009=\u20096 per treatment) to study the effect of mineral concentration in Study I (0, 100, 200 and 300\u2009mOsm\/kg), the K<jats:sup>+<\/jats:sup> to Na<jats:sup>+<\/jats:sup> ratio in Study II (25:75, 40:60, 60:40 and 75:25), and glycerol concentration in Study III (0%, 1%, 2% and 4% of the final solution). The blocking factor was initial BW and treatments were randomly assigned within each block. Measurements included fluid intakes, BW, and blood parameters at 0, 24 and 48\u2009h relative to the start of feed deprivation. In Study I, increasing mineral concentration in solution linearly decreased BW losses at 48\u2009h. At 24 and 48\u2009h, serum urea linearly decreased with increasing mineral concentration. At 48\u2009h, blood K<jats:sup>+<\/jats:sup> and Na<jats:sup>+<\/jats:sup> linearly increased, resulting in increased blood osmolarity. Additionally, at 24\u2009h feed deprivation, blood pH linearly increased with increasing osmolality. In Study II, BW losses decreased with increasing K<jats:sup>+<\/jats:sup> to Na<jats:sup>+<\/jats:sup> ratio at 24\u2009h, but not at 48\u2009h. No effect of the K<jats:sup>+<\/jats:sup> to Na<jats:sup>+<\/jats:sup> ratio was found on blood parameters, apart from a trend for a linear decrease of blood osmolarity at 48\u2009h. In Study III, serum urea tended to linearly decrease with increasing glycerol inclusion at 24\u2009h, while blood glucose linearly increased with glycerol inclusion at 24 and 48\u2009h. These combined results indicated that a solution with an osmolality of 200\u2009mOsm\/kg and a high K<jats:sup>+<\/jats:sup> to Na<jats:sup>+<\/jats:sup> ratio would effectively mitigate BW losses and maintain blood acid\u2013base balance, whereas high glycerol inclusion sustained blood glucose in feed\u2010deprived bulls.<\/jats:p>","DOI":"10.1111\/jpn.13700","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T09:43:43Z","timestamp":1648460623000},"page":"77-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mineral and glycerol concentrations in drinking water on body weight loss and acid\u2010base balance in feed\u2010deprived Holstein bulls"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1725-1087","authenticated-orcid":false,"given":"Juliette N.","family":"Wilms","sequence":"first","affiliation":[{"name":"Trouw Nutrition R&amp;D Amersfoort The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-3960","authenticated-orcid":false,"given":"Isabela P.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Trouw Nutrition R&amp;D Amersfoort The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireille","family":"van Empel","sequence":"additional","affiliation":[{"name":"Trouw Nutrition R&amp;D Amersfoort The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-4629","authenticated-orcid":false,"given":"Javier","family":"Mart\u00edn\u2010Tereso","sequence":"additional","affiliation":[{"name":"Trouw Nutrition R&amp;D Amersfoort The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2527\/1993.71171x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.15232\/S1080-7446(15)30443-5"},{"key":"e_1_2_7_4_1","first-page":"1","volume-title":"R. 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