{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:21:50Z","timestamp":1790295710083,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heat stress (HS) is the most substantial environmental issue in rabbit health status impairment, which can lower productivity. Maca is a common medicinal plant with important biological activities including antioxidant, anti\u2010inflammatory, anti\u2010fatigue, and neuroprotective effects. The present research explored the alleged protective role of Maca extract in alleviating the adverse impact of HS on rabbits. Growing V\u2010line 6\u2010week\u2010old buck rabbits (<jats:italic>N<\/jats:italic>\u2009=\u200948) were orally administered Maca extract at levels of 0 (MAC0), 200 (MAC2), 400 (MAC4), or 600 (MAC6) mg\/head twice per week. Compared to the control groups, rabbits provided Maca had better growth performance, feed intake and feed conversion ratio. Liver and tests weights were significantly higher (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in Maca treated groups compared to the control. hemoglobin, white blood cell, red blood corpuscles, platelet count, hematocrit, and lymphocytes were significantly increased in the MAC4 group compared with the control group. MAC4 treatment significantly reduced aspartate aminotransferase and malondialdehyde levels compared with other groups. Moreover, the concentrations of total bilirubin, creatinine, glucose, total cholesterol, and triglycerides were lower (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in the MAC4 group than in the controls. Oral administration of Maca improved cortisol and testosterone values, total antioxidant capacity, and superoxide dismutase. The MAC4 group exhibited significant improvement (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in sperm motility, survival, membrane functionality, concentration, and libido, with a significant decrease in abnormal sperm compared with the control group. Also, aforementioned group showed sperm cells with a normal structure and intact plasma membranes, acrosomes, and well\u2010organised axonemal components. Histopathological screening of liver sections showed moderate to severe degenerative and necrotic changes in rabbits exposed to HS, which were alleviated with Maca oral administration. In conclusion, oral administration of Maca extract at 400 or 600\u2009mg\/head\u2010weekly enhanced growth performance, hemato\u2010biochemical attributes, antioxidant status, and semen quality in rabbits during the hot season.<\/jats:p>","DOI":"10.1111\/jpn.13772","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T09:20:04Z","timestamp":1663147204000},"page":"286-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The benefits of Maca (<i>Lepidium meyenii<\/i>) extract administration for male rabbits affected by environmental heat stress"],"prefix":"10.1111","volume":"107","author":[{"given":"Mona A.","family":"Ragab","sequence":"first","affiliation":[{"name":"Animal Production Research Institute (APRI), Agriculture Research Center Ministry of Agriculture Dokki Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A. E.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Animal Production Research Institute (APRI), Agriculture Research Center Ministry of Agriculture Dokki Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheir A.","family":"Shazly","sequence":"additional","affiliation":[{"name":"Animal Production Research Institute (APRI), Agriculture Research Center Ministry of Agriculture Dokki Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed E.","family":"El\u2010Kholany","sequence":"additional","affiliation":[{"name":"Animal Production Research Institute (APRI), Agriculture Research Center Ministry of Agriculture Dokki Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed E.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Animal Production Research Institute (APRI), Agriculture Research Center Ministry of Agriculture Dokki Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1816-8701","authenticated-orcid":false,"given":"Ali Ali","family":"El\u2010Raghi","sequence":"additional","affiliation":[{"name":"Department of Animal Production, Faculty of Agriculture Damietta University Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13045"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2020.104220"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2018.12.013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4038\/jas.v17i1.9622"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2021.103075"},{"key":"e_1_2_10_7_1","volume-title":"Churchill Livingstone","author":"Bancroft J.D.","year":"2008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1079\/9781789241273.0000"},{"issue":"1","key":"e_1_2_10_9_1","first-page":"3","article-title":"Harmonization of criteria and terminology in rabbit meat research","volume":"1","author":"Blasco Mateu A.","year":"1993","journal-title":"World Rabbit Science"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2014.03.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2010.01.028"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731117000088"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.20.0258"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","unstructured":"Fouda S. 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