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The promising effects observed during the transition period resulting from supplementation with <jats:italic>Aloe arborescens<\/jats:italic> Mill. suggest its potential utility during this phase. A group of 23 Holstein dairy cows with somatic cell count (SCC) less than 200\u2009\u00d7\u200910<jats:sup>3<\/jats:sup> cells\/ml and without intramammary infections were enroled in the study. Cows were divided into two groups: one orally receiving 10\u2009g\/day of <jats:italic>A. arborescens<\/jats:italic> Mill. lyophilized powder (AL; 11 cows) between \u22127 and 7 days from dry\u2010off (DFD), and a control group (CTR; 12 cows). From \u221214 to 7 DFD and 7 and 28 days from calving, the body condition score and rectal temperature were determined, and rumen fluid, feces, milk, and blood samples were collected. Daily rumination times and milk yield were recorded. Data were analyzed through repeated measures mixed models. Compared to the CTR group, AL cows tended to show reduced production of volatile fatty acids in the rumen with acetate proportion that tended to be higher and valerate proportion that was lower. Moreover, <jats:italic>Aloe<\/jats:italic> supplementation caused a reduction in fecal dry matter. At the end of drying\u2010off, AL cows presented better liver function, as suggested by higher paraoxonase plasma concentrations at 7 DFD, higher glucose, and lower urea, but showed increased reactive oxygen metabolites. <jats:italic>Aloe<\/jats:italic> supplementation at dry\u2010off ameliorated inflammatory status after calving (lower haptoglobin and ceruloplasmin levels), and improved milk yield in the first weeks of subsequent lactation, without influencing milk composition, SCC, and incidence of intramammary infections. These results confirmed the positive effects of <jats:italic>Aloe<\/jats:italic> administration on liver function in dairy cows but indicate the need for further studies investigating the effects of <jats:italic>Aloe<\/jats:italic> on rumen fermentation profile and oxidative status.<\/jats:p>","DOI":"10.1111\/jpn.13777","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T09:08:23Z","timestamp":1665738503000},"page":"794-807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Drying\u2010off dairy cows without antibiotic therapy and orally supplemented with lyophilized <i>Aloe arborescens<\/i>: effects on rumen activity, immunometabolic profile, and milk yield"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6027-7536","authenticated-orcid":false,"given":"Luca","family":"Cattaneo","sequence":"first","affiliation":[{"name":"Department of Animal Science, Food and Nutrition (DIANA) Universit\u00e0 Cattolica del Sacro Cuore Piacenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1277-7821","authenticated-orcid":false,"given":"Fiorenzo","family":"Piccioli\u2010Cappelli","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Food and Nutrition (DIANA) Universit\u00e0 Cattolica del Sacro Cuore Piacenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-6571","authenticated-orcid":false,"given":"Andrea","family":"Minuti","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Food and Nutrition (DIANA) Universit\u00e0 Cattolica del Sacro Cuore Piacenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1644-1911","authenticated-orcid":false,"given":"Erminio","family":"Trevisi","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Food and Nutrition (DIANA) Universit\u00e0 Cattolica del Sacro Cuore Piacenza Italy"},{"name":"Romeo and Enrica Invernizzi Research Centre for Sustainable Dairy Production (CREI) Universit\u00e0 Cattolica del Sacro Cuore Piacenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12273"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2020-19782"},{"key":"e_1_2_8_4_1","unstructured":"ADAS.1986. 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