{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:10:03Z","timestamp":1784157003935,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hindgut fermenting herbivores from different vertebrate taxa, including tortoises, and among mammals some afrotheria, perissodactyla incl. equids, several rodents as well as lagomorphs absorb more calcium (Ca) from the digesta than they require, and excrete the surplus via urine. Both proximate and ultimate causes are elusive. It was suggested that this mechanism might ensure phosphorus availability for the hindgut microbiome by removing potentially complex\u2010building Ca from the digesta. Here we use Ussing chamber experiments to show that rabbits (<jats:italic>Oryctolagus cuniculus<\/jats:italic>) maintained on four different diets (six animals\/diet) increase active Ca absorption at increasing Ca levels. This contradicts the common assumption that at higher dietary levels, where passive uptake should be more prevalent, active transport can relax\u00a0and hence supports the deliberate removal hypothesis. In the rabbits, this absorption was distinctively higher in the caecum than in the duodenum, which is unexpected in mammals. Additional quantification of the presence of two proteins involved in active Ca absorption (calbindin\u2010D9K CB; vitamin D receptor, VDR) showed higher presence with higher dietary Ca. However, their detailed distribution across the intestinal tract and the diet groups suggests that other factors not investigated in this study must play major roles in Ca absorption in rabbits. Investigating strategies of herbivores to mitigate potential negative effects of Ca in the digesta on microbial activity and growth might represent a promising area of future research.<\/jats:p>","DOI":"10.1111\/jpn.13880","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T09:29:56Z","timestamp":1693819796000},"page":"185-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Rabbits (<i>Oryctolagus cuniculus<\/i>) increase caecal calcium absorption at increasing dietary calcium levels"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4292-8515","authenticated-orcid":false,"given":"Annette","family":"Liesegang","sequence":"first","affiliation":[{"name":"Institute of Animal Nutrition and Dietetics, Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Burger","sequence":"additional","affiliation":[{"name":"Clinic for Zoo Animals, Exotic Pets and Wildlife, Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9r\u00e8se","family":"de Vries de Heekelingen","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Anatomy University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Schroeter\u2010Vogt","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Anatomy University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7043-7430","authenticated-orcid":false,"given":"Jean\u2010Michel","family":"Hatt","sequence":"additional","affiliation":[{"name":"Clinic for Zoo Animals, Exotic Pets and Wildlife, Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4565-7714","authenticated-orcid":false,"given":"Mariusz P.","family":"Kowalewski","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Anatomy University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3841-6207","authenticated-orcid":false,"given":"Marcus","family":"Clauss","sequence":"additional","affiliation":[{"name":"Clinic for Zoo Animals, Exotic Pets and Wildlife, Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00036.2003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1655"},{"key":"e_1_2_10_4_1","volume-title":"Microscopic technique","author":"B\u00f6ck P.","year":"1989"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000102540"},{"key":"e_1_2_10_6_1","first-page":"176","article-title":"Calcium and phosphorus metabolism in chronically vitamin D\u2010deficient laboratory rabbits","volume":"12","author":"Bourdeau J. 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