{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:24:25Z","timestamp":1790223865516,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Advanced glycation end products (AGEs), formed via the Maillard reaction (MR) during processing of foods, have been implicated in inflammatory and degenerative diseases in human beings. Cellular damage is primarily caused by AGE binding with the receptor for AGEs (RAGE) on cell membranes. An isoform of RAGE, soluble RAGE (sRAGE), acts as a decoy receptor binding circulating AGEs preventing cellular activation. Pet food manufacturing involves processing methods similar to human food processing that may increase dietary AGEs (dAGEs). We hypothesized that diet, plasma and urine AGEs, and serum sRAGE concentrations would differ between thermally processed diets. This study examined the association of four differently processed diets: ultra\u2010processed canned wet food (WF); ultra\u2010processed dry food (DF); moderately processed air\u2010dried food (ADF)\u00a0and minimally processed mildly cooked food (MF) on total plasma levels of the AGEs, carboxymethyllysine (CML), carboxyethyllysine (CEL), methylglyoxal hydroimidazolone\u20101, glyoxal hydroimidazolone\u20101, argpyrimidine, urine CML, CEL and lysinoalanine, and serum sRAGE concentration. Ultra\u2010high\u2010performance liquid chromatography\u2013tandem mass spectrometry\u00a0was used to measure AGEs. sRAGE concentration was measured using a commercial canine\u2010specific enzyme\u2010linked immunosorbent assay\u00a0kit. Total dAGEs (mg\/100\u2009kcal as fed) were higher in WF than in other diets. Plasma total AGEs (nM\/50\u2009\u03bcL) were significantly higher with WF, with no difference found between DF, ADF, and MF; however, ADF was significantly higher than MF. Urine CML (nmol AGEs\/mmol creatinine) was significantly higher with DF than with WF and MF. There were no significant differences in total urine AGEs or serum sRAGE concentration between diets. In conclusion, different methods of processing pet foods are associated with varied quantities of AGEs influencing total plasma AGE concentration in healthy dogs. Serum sRAGE concentration did not vary across diets but differences in total AGE\/sRAGE ratio were observed between MF and WF and, ADF and DF.<\/jats:p>","DOI":"10.1111\/jpn.13927","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T15:38:27Z","timestamp":1706369907000},"page":"735-751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of four differently processed diets with plasma and urine advanced glycation end products and serum soluble receptor for advanced glycation end products concentration in healthy dogs"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6588-2863","authenticated-orcid":false,"given":"Siobhan","family":"Bridglalsingh","sequence":"first","affiliation":[{"name":"Department of Small Animal Medicine and Surgery University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Archer\u2010Hartmann","sequence":"additional","affiliation":[{"name":"Analytical Services, Complex Carbohydrate Research Center University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parastoo","family":"Azadi","sequence":"additional","affiliation":[{"name":"Analytical Services, Complex Carbohydrate Research Center University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Barbier de La Serre","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Colorado State University, Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Remillard","sequence":"additional","affiliation":[{"name":"Veterinary Nutritional Consultations, Inc. Hollister North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory D.","family":"Sunvold","sequence":"additional","affiliation":[{"name":"Sunvold Technology, LLC Lewisburg Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7085-1420","authenticated-orcid":false,"given":"Joseph W.","family":"Bartges","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2017.1378865"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-005-0688-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0119-z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2021.110216"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1324"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.08.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3619-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2012-0823"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101958"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf950394r"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2016.1152949"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac400294q"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2014.08.003"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.11.014"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201200255"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuv030"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2019.1693958"},{"key":"e_1_2_9_19_1","first-page":"66","article-title":"Action of amino acids on sugars. 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