{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:26:03Z","timestamp":1740126363083,"version":"3.37.3"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,4]],"date-time":"2024-02-04T00:00:00Z","timestamp":1707004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSPD2024R971"],"award-info":[{"award-number":["RSPD2024R971"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objectives of the present study were to investigate the potential effects of purified bee venom (BV) on various aspects of growth, carcass, antioxidant, intestinal bacterial count\u00a0and economic considerations in rabbits. A total of 240 male rabbits, comprising two distinct breeds (V\u2010Line and New Zealand White [NZW]), 5\u00a0weeks old, with an average live body weight (BW) of 680\u2009\u00b1\u200920\u2009g, were randomly divided into six groups, each containing 30 rabbits. Each group had five replicates, with six rabbits in each replicate. The allocation of animals to the groups followed a fully factorial design, incorporating two factors: breed (V\u2010Line and NZW) and four levels of purified BV derived from <jats:italic>Apis Mellifera<\/jats:italic>. The control group (G1) received a basal diet without additives. The other three groups (G2, G3\u00a0and G4) received the basal diet with BV supplementation in their drinking water at 0.5, 1\u00a0and 2\u2009mg\/L\u00a0respectively. The study results indicated that NZW rabbits significantly enhanced feed conversion ratio while maintaining consistent carcass attributes compared to the V\u2010Line breed. Despite variations in growth parameters being less pronounced, the supplementation of BV at levels of 1\u20132\u2009mg\/L demonstrated significant improvements in various other parameters. Notably, the interaction between the BV supplement and the breed factor (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) yielded notable distinctions in most production metrics, encompassing BW, weight gain, feed conversion, carcass attributes\u00a0and blood parameters. Increasing levels of BV supplementation, particularly at 1\u2009mg\/L, led to substantial improvements in serum and tissue metabolites. Moreover, the levels of total bacterial count and <jats:italic>Escherichia coli<\/jats:italic> in the jejunum and colon were significantly diminished, while the population of <jats:italic>Lactobacilli<\/jats:italic> in the colon was augmented (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in rabbits from both breeds receiving BV supplementation (1\u20132\u2009mg\/L) compared to the control group. The results underscore the potential of the BV supplement to enhance final weights, bolster antioxidant status\u00a0and mitigate the presence of pathogenic bacteria, thereby contributing to enhanced economic efficiency in rabbits. Further inquiries are warranted to comprehensively investigate BV supplementation's potential advantages and limitations across different breeds and dosage levels.<\/jats:p>","DOI":"10.1111\/jpn.13931","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T05:23:52Z","timestamp":1707110632000},"page":"792-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of bee venom supplement on productive performance, health status and economics of weaned male rabbits: Considering breed and dosage factors"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8306-0011","authenticated-orcid":false,"given":"Ayman H.","family":"Abd El\u2010Aziz","sequence":"first","affiliation":[{"name":"Animal Husbandry and Animal Wealth Development Department, Faculty of Veterinary Medicine Damanhour University Damanhour Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagwa I.","family":"El\u2010Kasrawy","sequence":"additional","affiliation":[{"name":"Animal Husbandry and Animal Wealth Development Department, Faculty of Veterinary Medicine Damanhour University Damanhour Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-8534","authenticated-orcid":false,"given":"Mohamed E.","family":"Abd El\u2010Hack","sequence":"additional","affiliation":[{"name":"Poultry Department, Faculty of Agriculture Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3247-5898","authenticated-orcid":false,"given":"Ayman A.","family":"Swelum","sequence":"additional","affiliation":[{"name":"Department of Animal Production, College of Food and Agriculture Sciences King Saud University Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamaleldin","family":"Suliman","sequence":"additional","affiliation":[{"name":"Department of Animal Production, College of Food and Agriculture Sciences King Saud University Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Tufarelli","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Jonian Area (DiMePRe\u2010J) Section of Veterinary Science and Animal Production, University of Bari Aldo Moro Valenzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1788-5082","authenticated-orcid":false,"given":"Mahmoud M.","family":"Abo Ghanima","sequence":"additional","affiliation":[{"name":"Animal Husbandry and Animal Wealth Development Department, Faculty of Veterinary Medicine Damanhour University Damanhour Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12121528"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10495398.2020.1800485"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10030452"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2022.101696"},{"issue":"3","key":"e_1_2_9_6_1","first-page":"221","article-title":"Effects of Nigella sativa oil and ascorbic acid against oxytetracycline\u2010induced hepato\u2010renal toxicity in rabbits","volume":"18","author":"Abdel\u2010Daim M. M.","year":"2015","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13049"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/1828051X.2020.1815598"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.21608\/jaesj.2023.206783.1081"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.21608\/jappmu.2014.69561"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.spid.2004.01.010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.573159"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2008-00244"},{"key":"e_1_2_9_14_1","first-page":"3","article-title":"Harmonization of criteria and terminology in rabbit meat research","volume":"1","author":"Blasco Mateu A.","year":"1993","journal-title":"World Rabbit Science"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi049390i"},{"issue":"6","key":"e_1_2_9_16_1","first-page":"470","article-title":"A phase I study of the safety of honeybee venom extract as a possible treatment for patients with progressive forms of multiple sclerosis","volume":"26","author":"Castro H. J.","year":"2005","journal-title":"Allergy and Asthma Proceedings"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2009.09.012"},{"issue":"2","key":"e_1_2_9_18_1","first-page":"257","article-title":"Effects of honeybee (Apis mellifera) venom on redox balance, biochemical and hematological profile in diabetic rats: A preliminary study","volume":"45","author":"Denk B.","year":"2021","journal-title":"Turkish Journal of Veterinary & Animal Sciences"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-6226(01)00331-1"},{"issue":"2","key":"e_1_2_9_20_1","first-page":"246","article-title":"Therapeutic application of anti\u2010arthritis, pain\u2010releasing, and anti\u2010cancer effects of bee venom and its constituent compounds","volume":"5","author":"Dong J. S.","year":"2007","journal-title":"Pharmacology and Therapeutics"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejnf.2023.298109"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2020.112987"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13552"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejrs.2022.268253"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13227"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2003.11.013"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8188-x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/00218839.2006.11101331"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.7853\/kjvs.2016.39.3.159"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2012.698402"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x09006813"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2010-00915"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41936-019-0127-x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.21608\/epsj.2021.159922"},{"issue":"4","key":"e_1_2_9_35_1","first-page":"136","article-title":"Medical importance of bee products","volume":"12","author":"Hegazi A. G.","year":"2012","journal-title":"Uluda\u011f Ar\u0131c\u0131l\u0131k Dergisi"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0160-9327(88)90082-8"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.21608\/epsj.2021.197896"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-010-0052-8"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.13-0045"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.22207\/JPAM.12.4.48"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/00071668.2018.1476675"},{"key":"e_1_2_9_42_1","first-page":"65","article-title":"Effect on antibody titer to hog cholera, Mycoplasma hyopneumoniae and atropic rhinitis vaccines after bee venom acupuncture in pigs","volume":"1","author":"Kwon Y. B.","year":"2001","journal-title":"Journal of Veterinary Medicine and Biotechnology"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(96)03075-8"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1994.tb00444.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765201520130511"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/369324"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.52.070183.003431"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins7041126"},{"volume-title":"Nutrient requirements of rabbits","year":"1977","author":"National Research\u00a0Council","key":"e_1_2_9_49_1"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/0003942032000161054"},{"issue":"12","key":"e_1_2_9_51_1","first-page":"743","article-title":"Studies on the antibacterial properties of bee venom","volume":"10","author":"Ortel S.","year":"1955","journal-title":"Die Pharmazie"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2006.03161.x"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12091108"},{"issue":"2","key":"e_1_2_9_54_1","first-page":"533","article-title":"Influence of some honey bee products on some hematological and immunological parameters and meat quality in broilers","volume":"38","author":"Rabie A. H.","year":"2018","journal-title":"Egyptian Poultry Science Journal"},{"issue":"8","key":"e_1_2_9_55_1","first-page":"912","article-title":"Antioxidant activity of and interleukin production affected by honey bee venom","volume":"40","author":"Rekka E.","year":"1990","journal-title":"Arzneimittel\u2010Forschung"},{"key":"e_1_2_9_56_1","first-page":"209","article-title":"Biochemical study on the regenerative effect of bee venom on experimentally induced diabetes","volume":"10","author":"El Senosi Y. A.","year":"2018","journal-title":"World Journal of Pharmacology and Pharmaceutical Sciences"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.129124"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3940(02)01325-3"},{"volume-title":"Apitoxin: From bee venom to apitoxin for medical use","year":"2005","author":"Urtubey N.","key":"e_1_2_9_59_1"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3938\/jkps.62.320"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.3831\/KPI.2016.19.023"}],"container-title":["Journal of Animal Physiology and Animal Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpn.13931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T04:15:48Z","timestamp":1715055348000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpn.13931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,4]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/jpn.13931"],"URL":"https:\/\/doi.org\/10.1111\/jpn.13931","archive":["Portico"],"relation":{},"ISSN":["0931-2439","1439-0396"],"issn-type":[{"type":"print","value":"0931-2439"},{"type":"electronic","value":"1439-0396"}],"subject":[],"published":{"date-parts":[[2024,2,4]]},"assertion":[{"value":"2023-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}