{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:15:42Z","timestamp":1770833742831,"version":"3.50.1"},"reference-count":85,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This experiment was designed to investigate the impact of curcumin\u2010olive oil nanocomposite (CONC) supplementation on uteroplacental hemodynamics and ultrasonographic measurements as well as maternal oxidative status in midgestating goats. Twelve synchronized pregnant goats (85.58\u2009\u00b1\u20091.08 days of gestation; mean\u2009\u00b1\u2009SD) were uniformly assigned to two groups (<jats:italic>n<\/jats:italic>\u2009=\u20096\/group); the first group received daily oral supplementation of CONC (3\u2009mg\/kg body weight; nanocurcumin [NC] group) for 32 days, and the second group was offered physiological saline (control) following the NC group timeline. The goats of both groups were examined at 3\u2010day intervals for middle uterine (MUA) and umbilical (UMA) arteries hemodynamics (pulsatility index [PI], resistive index [RI], systole\/diastole [S\/D] and blood flow rate [BFR]) and diameters, uteroplacental thickness (UPT), placentomes' diameter (PD) and echogenicity, steroid hormones (progesterone and estradiol 17\u03b2), oxidative biomarkers (total antioxidant capacity [TAC], catalase [CAT], malondialdehyde [MDA]), nitric oxide (NO) and blood cells DNA integrity. The UPT (<jats:italic>p<\/jats:italic>\u2009=\u20090.012) and PD (<jats:italic>p<\/jats:italic>\u2009=\u20090.021) values were higher in the NC group than in their counterparts' control group (D11\u201332). There were increases in diameter (<jats:italic>p<\/jats:italic>\u2009=\u20090.021 and <jats:italic>p<\/jats:italic>\u2009=\u20090.012) and decreases (<jats:italic>p<\/jats:italic>\u2009=\u20090.021, <jats:italic>p<\/jats:italic>\u2009=\u20090.016 and <jats:italic>p<\/jats:italic>\u2009=\u20090.041 [MUA]; <jats:italic>p<\/jats:italic>\u2009=\u20090.015, <jats:italic>p<\/jats:italic>\u2009=\u20090.023 and <jats:italic>p<\/jats:italic>\u2009=\u20090.011 [UMA] respectively) in Doppler indices (PI, RI and S\/D) of the MUA and UMA in the NC group compared to the control group (D14\u201332). On D20\u201332 (MUA) and D14\u201332 (UMA), the NC goats had higher BFR than the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.021, 0.018 respectively). The means of blood cells with fragmented DNA were lower (<jats:italic>p<\/jats:italic>\u2009=\u20090.022) in the NC group than in the control group on Days 8 and 21 postsupplementation. There were increases in CAT and NO (D20\u201332; <jats:italic>p<\/jats:italic>\u2009=\u20090.022 and <jats:italic>p<\/jats:italic>\u2009=\u20090.004 respectively), and TAC (D17\u201332; <jats:italic>p<\/jats:italic>\u2009=\u20090.007) levels in the NC goats compared to the control ones. The NC group had lower (<jats:italic>p<\/jats:italic>\u2009=\u20090.029) concentrations of MDA than the control group on Day 20 postsupplementation onward. In conclusion, oral supplementation of CONC improved uteroplacental blood flow and the antioxidant capacity of midgestating goats.<\/jats:p>","DOI":"10.1111\/jpn.13933","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T15:19:06Z","timestamp":1707319146000},"page":"839-853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Maternal supplementation of curcumin\u2010olive oil nanocomposite improves uteroplacental blood flow, placental growth and antioxidant capacity in goats"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0069-9926","authenticated-orcid":false,"given":"Hossam R.","family":"El\u2010Sherbiny","sequence":"first","affiliation":[{"name":"Theriogenology Department, Faculty of Veterinary Medicine Cairo University Giza 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Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled H.","family":"El\u2010Shahat","sequence":"additional","affiliation":[{"name":"Theriogenology Department, Faculty of Veterinary Medicine Cairo University Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal M.","family":"Aboelmaaty","sequence":"additional","affiliation":[{"name":"Animal Reproduction and Artificial Insemination Department, National Research Centre Veterinary Research Institute Dokki Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karima F.","family":"Mahrous","sequence":"additional","affiliation":[{"name":"Cell Biology Department, National Research Centre Biotechnology Research Institute Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid M.","family":"Al Syaad","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science King Khalid University Abha Saudi 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