{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:42:10Z","timestamp":1792122130798,"version":"4.4.0"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reducing the dietary crude protein (CP) could effectively reduce pressure on protein ingredient supplies. However, few data have been reported about the extent to which CP can be reduced and whether limiting the use of soybean meal leads to electrolyte imbalance. In this experiment, using the low protein (LP) diet [2% lower than NRC (2012)], seventy\u2010two piglets (35 days old) were randomly divided into 2 groups with 6 replicates of 6 piglets each: CON group (CP\u2009=\u200918.5%) and LP group (CP\u2009=\u200916.5%), to investigate the effect of the LP diet on electrolyte balance, acid\u2010base balance, intestinal structure and amino acid transport in piglets. The results revealed that the LP diet decreased the average daily gain and dietary CP digestibility, and damaged the villi structure of the small intestine. Compared with the CON diet, the potassium content decreased and the chlorine content increased in the LP diet, and similar trends were shown in piglet serum. The arterial pH, pCO<jats:sub>2<\/jats:sub>, HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup>, and base excess of piglets in the LP group were lower than those in the CON group, while pO<jats:sub>2<\/jats:sub> was higher than those in the CON group. Interestingly, the LP diet significantly increased the lysine content in piglet serum and significantly decreased the levels of arginine, leucine, and glutamic acid. Furthermore, the LP diet significantly affected the expression of some amino acid transport vectors (B<jats:sup>0<\/jats:sup>AT1, EAAC1, and y<jats:sup>+<\/jats:sup>LAT1). In summary, these findings suggested that the LP diet leads to acid\u2010base imbalance, amino acid transport disorder and amino acids imbalance in piglets, and the dietary electrolyte may be a key factor in the impact of the LP diet on piglet growth performance and intestinal health.<\/jats:p>","DOI":"10.1111\/jpn.13954","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T12:54:23Z","timestamp":1712148863000},"page":"1107-1118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of low protein diets on acid\u2010base balance, electrolyte balance, intestinal structure, and amino acid transport in piglets"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6111-6195","authenticated-orcid":false,"given":"Qian","family":"Lin","sequence":"first","affiliation":[{"name":"College of Animal Sciences, Key Laboratory of Molecular Animal Nutrition 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