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A total of 96 growing rabbits were randomly distributed into four treatments, with 24 rabbits in each group. The rabbits were fed a basal diet (control group) or a diet supplemented with MO at 0.5 (MO0.5), 1 (MO1.0)\u00a0and 2 (MO2.0) mL\/kg of diet for eight weeks. The daily body weight gain and feed conversion ratio showed a quadratic improvement with increasing levels of MO, and the optimal dose was 1.25\u2009mL\/kg of diet. Increasing levels of MO also had a quadratic effect on hepatic and renal functions. Dose\u2010response curves revealed that the optimal doses of MO were 1.50, 1.75\u00a0and 1.25\u2009mL\/kg of diet for total bilirubin, gamma\u2010glutamyl transferase, and creatinine\u00a0respectively. A quadratic relationship was observed between the increased levels of MO and tumour necrosis factor\u2010\u03b1 (<jats:italic>p<\/jats:italic>\u2009=\u20090.038), interleukin\u20106 (<jats:italic>p<\/jats:italic>\u2009=\u20090.014)\u00a0and immunoglobulins (<jats:italic>p<\/jats:italic>\u2009=\u20090.016 and IgM <jats:italic>p<\/jats:italic>\u2009=\u20090.026). Additionally, a linear relationship was observed between the increment in MO levels and both nitric oxide (<jats:italic>p<\/jats:italic>\u2009=\u20090.040) and interleukin\u20104 (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). The activities of superoxide dismutase and glutathione peroxidase showed a linear increase with increasing dietary MO content, while xanthine oxidase showed a linear decrease. Total antioxidant capacity showed quadratic improvement (<jats:italic>p<\/jats:italic>\u2009=\u20090.035) with the dietary treatment, with the optimal dose observed at 1.25\u2009mL\/kg of diet. The inclusion of MO in the diet had a linear effect on the activity of thyroxine (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Therefore, supplementation of MO at a dose of 1 or 1.5\u2009mL\/kg of diet in growing rabbits'\u00a0diets can improve growth and carcass traits, sustain thyroid function by supporting immunity, and reduce oxidative\/inflammation pathways.<\/jats:p>","DOI":"10.1111\/jpn.14014","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T05:39:29Z","timestamp":1719985169000},"page":"1734-1746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of dietary supplementation of macadamia oil on the growth, immune function, physio\u2010biochemical components\u00a0and thyroid activity of growing rabbits"],"prefix":"10.1111","volume":"108","author":[{"given":"Fatima A.","family":"Jaber","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, College of Science University of Jeddah Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samia","family":"Nasr","sequence":"additional","affiliation":[{"name":"Chemistry Department, College of Science King Khalid University Abha Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan M. 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