{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T21:54:20Z","timestamp":1763330060930,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objectives were to determine the interactive effect of particle size of soyabean meal (SBM) and whole wheat, barley and wheat bran (CER) on growth performance of weanling pigs after an enterotoxigenic <jats:italic>Escherichia coli<\/jats:italic> F4 challenge (Experiment 1) and on gastrointestinal (GIT) development immediately after weaning (Experiment 2). Experiment 1 consisted of 192 pigs (24\u2009\u00b1\u20093 days of age; 7.4\u2009\u00b1\u20091.1\u2009kg weaning bodyweight [BW]) selected for <jats:italic>Escherichia coli<\/jats:italic> (<jats:italic>E. coli<\/jats:italic>) F4 susceptibility. Pigs were given an oral <jats:italic>E. coli<\/jats:italic> inoculum at postweaning day 7, to induce an enteric health challenge. Experiment 2 consisted of 40 pigs (24\u2009\u00b1\u20093 days of age; 7.2\u2009\u00b1\u20091.0\u2009kg weaning BW) that were killed on postweaning day 8 or 9, to determine the effects of particle size on GIT development and functionality. Four experimental diets were used in a 2\u2009\u00d7\u20092 factorial design: (1) coarse CER and coarse SBM, (2) coarse CER and fine SBM (CERcSBMf), (3) fine CER and coarse SBM, or (4) fine CER and fine SBM (CERfSBMf). Results showed no interaction between SBM and CER coarseness on growth performance, GIT development and functionality. Diarrhoea incidence was higher (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) for CERfSBMf during the 2 weeks following the <jats:italic>E. coli<\/jats:italic> challenge compared to the other diets. Daily gain and feed intake during this period were higher (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) for pigs fed CERc compared to CERf. Empty stomach weight tended to be greater by 8% (<jats:italic>p<\/jats:italic>\u2009=\u20090.09) for CERc compared to CERf. Gastric protein (<jats:italic>p<\/jats:italic>\u2009=\u20090.05) and starch (<jats:italic>p<\/jats:italic>\u2009=\u20090.04) disappearances were greater for SBMf compared to SBMc. Thus, CERcSBMf resulted in the best growth performance and lowest diarrhoea incidence during the 2 weeks following the <jats:italic>E. coli<\/jats:italic> challenge, which may be explained by changes in stomach functionality but not by changes in other parts of the GIT.<\/jats:p>","DOI":"10.1111\/jpn.14016","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T12:24:30Z","timestamp":1720614270000},"page":"1771-1785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of particle size of cereals and soyabean meal on the intestinal development of weanling pigs and growth performance after an enteric challenge with F4\u2010positive enterotoxigenic <i>E. coli<\/i>"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2020-4281","authenticated-orcid":false,"given":"Tetske G.","family":"Hulshof","sequence":"first","affiliation":[{"name":"Trouw Nutrition Research and Development Amersfoort The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2705-7686","authenticated-orcid":false,"given":"Jan Willem","family":"Resink","sequence":"additional","affiliation":[{"name":"Trouw Nutrition Research and Development Amersfoort The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1457-1731","authenticated-orcid":false,"given":"Hub\u00e8rt M. 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