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In this study, 350 1\u2010day\u2010old male Ross 308 broiler chicks were distributed among 35 pens in a completely randomized design with seven treatments, five replicates and 10 chicks in each replicate. The experimental treatments included: basal diet without any additives (control), basal diet\u2009+\u2009Avilamycin antibiotic, basal diet\u2009+\u2009200, 400, 600, 800 and 1000\u2009mg of peptides per kg of diet. Results showed no significant effects of the experimental treatments on weight gain and feed conversion ratio during the starter period, but there was a significant improvement in weight gain in grower, finisher and whole periods in chicks fed with diet containing 1000\u2009mg\/kg peptides (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Adding peptides improved intestinal morphology (in duodenum and ileum) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Supplementation of casein peptides significantly reduced thiobarbituric acid reactive substances concentration in breast and thigh meat. The activity of amylase, lipase and protease enzymes improved in treatments containing 800 and 1000\u2009mg peptides in comparison to the control treatment. The use of casein\u2010peptides increased intestinal <jats:italic>Lactobacillus<\/jats:italic> and decreased <jats:italic>Coliform<\/jats:italic> populations.<\/jats:p>","DOI":"10.1111\/jpn.14021","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T05:34:02Z","timestamp":1721021642000},"page":"1798-1806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of casein bioactive peptides on performance, nutrient digestibility, enzyme activity and intestinal microbial population in broiler chickens"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7657-5519","authenticated-orcid":false,"given":"Raziyeh","family":"Mokhtari","sequence":"first","affiliation":[{"name":"Department of Animal Science, College of Animal Science and Fisheries Sari Agricultural Sciences and Natural Resources University Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1880-343X","authenticated-orcid":false,"given":"Mohammad Kazemi","family":"Fard","sequence":"additional","affiliation":[{"name":"Department of Animal Science, College of Animal Science and Fisheries Sari Agricultural Sciences and Natural Resources University Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0515-6365","authenticated-orcid":false,"given":"Mansour","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Department of Animal Science, College of Animal Science and Fisheries Sari Agricultural Sciences and Natural Resources University Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0773-3966","authenticated-orcid":false,"given":"Essa","family":"Dirandeh","sequence":"additional","affiliation":[{"name":"Department of Animal Science, College of Animal Science and Fisheries Sari Agricultural Sciences and Natural Resources University Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/JAN.2017.6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-022-03244-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-022-03232-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/55.1.299s"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00071668.2013.838746"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2307\/3001478"},{"key":"e_1_2_8_8_1","article-title":"Pearson's chemical analysis of foods","volume":"9","author":"Egan H.","year":"1997","journal-title":"Journal of Food Science"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/86.6.1149"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4141\/cjas79-081"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)57021-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2007.01.013"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00071668.2019.1686122"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4141\/cjas2012-090"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00056-05"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2007-0414"},{"issue":"1","key":"e_1_2_8_17_1","first-page":"27","article-title":"Effects of canola bioactive peptides on performance, digestive enzyme activities, nutrient digestibility, intestinal morphology and gut microflora in broiler chickens","volume":"4","author":"Karimzadeh S.","year":"2016","journal-title":"Poultry Science Journal"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2017.06.013"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idairyj.2005.10.012"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2014.07.011"},{"key":"e_1_2_8_21_1","first-page":"963","article-title":"Purification and characterization of hevin, a serin protease from Hevea brazilliensis","volume":"23","author":"Lynn K. 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