{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T04:03:51Z","timestamp":1742443431039,"version":"3.40.1"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The study was conducted to evaluate the effect of butaphosphan and cyanocobalamin (BC) on the metabolic profile, oxidative stress in Kashmiri merino ewes and its effect on the prophylaxis of Ovine pregnancy toxemia (PT). A total of 48 ewes were randomly divided into three groups, each consisting of 16 ewes. High dose BC (HBC): Ewes were given 0.2\u2009mL BC\/kg body weight, subcutaneously (SC) weekly from 6 weeks pre\u2010lambing to lambing. Low dose BC (LBC): Ewes were given 0.1\u2009mL BC\/kg body weight, SC weekly from 6 weeks pre\u2010lambing to lambing. No BC (CON): Ewes were given 0.2\u2009mL normal saline\/kg body weight, SC. Weekly from six pre\u2010lambing to lambing. A significant effect of treatment was observed on non\u2010esterified fatty acid (NEFA; <jats:italic>p<\/jats:italic>\u2009=\u20090.06), beta hydroxybutyric acid (\u03b2\u2010HBA, <jats:italic>p<\/jats:italic>\u2009=\u20090.008), fructosamine (<jats:italic>p<\/jats:italic>\u2009=\u20090.034) and oxidative stress indices (OSI; <jats:italic>p<\/jats:italic>\u2009=\u20090.026) with less NEFA, \u03b2\u2010HBA, OSI and more fructosamine levels in HBC followed by LBC. The BC did not affect glucose, cholesterol, blood urea nitrogen, creatinine, total antioxidant capacity, calcium and phosphorus however a significant difference was observed along the sampling time in all the three groups. Plasma triglyceride, aspartate aminotransferase and total oxidant status levels showed a significant treatment\u2010time interaction. Taking 0.8\u2009mmol\/L \u03b2\u2010HBA as the cutoff limit for subclinical PT, only HBC was able to significantly control PT at 3 weeks pre\u2010lambing (OR; 5.57; <jats:italic>p<\/jats:italic>\u2009=\u20090.035), at 2 weeks pre\u2010lambing (OR: 9.53; <jats:italic>p<\/jats:italic>\u2009=\u20090.007), at 1\u2010week pre\u2010lambing (OR: 6.60; <jats:italic>p<\/jats:italic>\u2009=\u20090.017) and at lambing (OR: 5.57; <jats:italic>p<\/jats:italic>\u2009=\u20090.035). In conclusion, there was a positive effect of BC treatment on the energy metabolism in pregnant ewes and it helped in the amelioration of oxidative stress and hence can be used in the prophylaxis of PT.<\/jats:p>","DOI":"10.1111\/jpn.14069","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T05:18:26Z","timestamp":1731561506000},"page":"495-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Butaphosphan and Cyanocobalamin on the Metabolic Profile, Oxidative Stress and Prophylaxis of Ovine Pregnancy Toxemia"],"prefix":"10.1111","volume":"109","author":[{"given":"Raja","family":"Iqbal","sequence":"first","affiliation":[{"name":"Division of Clinical Veterinary Medicine Ethics and Jurisprudence, F.V. 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