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Collagen hydrolysates (CH) are a nutritional supplement that may exert anabolic effects on osteoarthritic joint cartilage as well as disease\u2010modifying effects. After oral intake, CH is absorbed, mainly as amino acids, di\u2010 and tripeptides that are transported amongst others to the joint. In addition to reducing cartilage degradation, CH metabolites may reduce synovial inflammation and subchondral bone sclerosis during OA. Preliminary evidence in dogs suffering from the consequences of OA support the clinical efficacy of CH with reported reductions in lameness. However, effects on biomarker level of cartilage metabolism and inflammation are inconclusive. Additionally, current studies show a lack of standardised dosing regimens and the use of not validated outcomes. Future work should therefore elucidate further on the bioavailability of CH in dogs in order to establish adequate dosing recommendations. Furthermore, high\u2010quality placebo\u2010controlled randomised controlled trials are essential to dstudies have evaluated the cetermine the clinical efficacy of CH to reduce lameness, prevent OA progression and thereby improve the level of evidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpn.14076","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T05:10:18Z","timestamp":1732770618000},"page":"590-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Collagen Hydrolysates as Nutritional Support in Canine Osteoarthritis: A Narrative Review"],"prefix":"10.1111","volume":"109","author":[{"given":"Niels R.","family":"Blees","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0534-4219","authenticated-orcid":false,"given":"Britta","family":"Dobenecker","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Chair of Animal Nutrition and Dietetics Ludwig\u2010Maximilians\u2010Universit\u00e4t Munich Oberschleissheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Prawitt","sequence":"additional","affiliation":[{"name":"Rousselot BV Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna A.","family":"Tryfonidou","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0740-1600","authenticated-orcid":false,"given":"Ronald","family":"Jan Corbee","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23940z"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.00220"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1082013211428219"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsfoodscitech.3c00588"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.103982"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.06.011"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-015-4349-z"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12479"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2020.105198"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3844\/ajavsp.2010.102.106"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073693"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243819"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.233.8.1278"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.237.1.66"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2018.02.017"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217750088"},{"key":"e_1_2_11_18_1","first-page":"93","article-title":"Canine Gait Analysis","volume":"6","author":"Carr B. 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