{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:30:16Z","timestamp":1765269016463,"version":"3.41.0"},"reference-count":90,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T00:00:00Z","timestamp":1734825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Lepidium meyenii<\/jats:italic> (Maca) is a plant that has nutritional benefits and increases the effectiveness of male reproduction. In this study, oxidative stress\u2010exposed New Zealand rabbits were used to assess the ameliorative effects of daily Maca ingestion on testicular and epididymal tissues as well as the quality of fresh and frozen\/thawed sperm. Twenty\u2010four 40\u2010week\u2010old, healthy New Zealand white male rabbits were divided into four groups. The first group consumed tap water and served as a control. The second group was given 300\u2009mg of Maca daily in capsules. The third group drank water containing hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) at a concentration of 1%. Finally, the fourth group consumed H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> and Maca daily. The ejaculate volume, sperm concentration, vitality, motility and velocity of the H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> group were considerably lower than those of the other groups. Frozen\/thawed spermatozoa showed more dramatic decreases in motility and velocity as a result of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> consumption. The plasma concentrations of testosterone and total antioxidant capacity were also lowest in the H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010treated rabbits, while malondialdehyde levels were highest. Exposure to H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> increased collagen deposition between ST and epididymal ducts which induced testicular and epididymis fibrosis. In addition, the spermatogenic and epididymal epithelial cells exhibited signs of apoptosis, degeneration, vacuolation and a reduction in height. Maca intake attenuated most of the damaging effects of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> ingestion\u2010induced oxidative stress. Furthermore, H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010treated rabbits had modest nuclear androgen receptor positivity, unlike those in the Maca group. The number of Leydig cells significantly increased with daily Maca intake. In conclusion, daily intake of Maca improved reproductive performance and mitigated the damaging effects of oxidative stress on testicular and epididymal functions in New Zealand rabbits.<\/jats:p>","DOI":"10.1111\/jpn.14083","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T06:18:42Z","timestamp":1734934722000},"page":"682-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Attenuation of Chronic Oxidative Stress\u2010Induced Testicular and Epididymal Dysfunction by Oral Intake of <i>Lepidium meyenii<\/i> in New Zealand Rabbits"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0079-7817","authenticated-orcid":false,"given":"Mohamed A. 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