{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T11:15:59Z","timestamp":1768648559657,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Food allergy is defined as an abnormal immune system response to the ingestion of certain ingredients or food additives. Beta\u2010glucans may support the management of obesity, particularly due to their immunomodulatory properties. However, the possible adverse reactions of this nutraceutical are little known. This report documents an allergic skin reaction in a 6\u2010year\u2010old obese mixed\u2010breed dog after consuming 0.1% purified beta\u20101,3\/1,6\u2010glucans from <jats:italic>Saccharomyces Cerevisiae<\/jats:italic> and subsequent dermatological signs after ingesting beta\u20101,3\u2010glucans from <jats:italic>Euglena gracilis<\/jats:italic>. The dog was enrolled in a clinical trial designed to evaluate the effects of two types of beta\u2010glucans on digestive, immunological, and intestinal health in obese dogs. Three nutritionally similar extruded dry diets were utilized: a control (CTL) diet without beta\u2010glucans, beta\u2010glucan A (BGA) containing 0.1% beta\u20101,3\/1,6\u2010glucans, and beta\u2010glucan B (BGB) with 0.1% beta\u20101,3\u2010glucans. Initially, the dog was deemed healthy, with all clinical parameters being within normal ranges. After a 30\u2010day adaptation period consuming the CTL diet, the dog was randomized to the BGA diet. Within 30 days, the owner reported intense pruritus, alopecia, and erythema in various areas. A nutritional consultation confirmed that the dog had never been exposed to beta\u2010glucans before. The CTL diet was reinstated, resulting in symptom resolution within 1 week. Following a subsequent challenge with the BGA diet, dermatological manifestations reemerged after 14 days but again resolved after returning to the CTL diet. The owner then agreed to a challenge with the BGB diet, leading to the reappearance of clinical signs after 15 days. The CTL diet was reintroduced, resulting in symptom resolution within ten days. However, the owner declined further testing with the BGB diet. This case concludes that the dog exhibited allergic reactions to purified beta\u20101,3\/1,6\u2010glucans from <jats:italic>Saccharomyces cerevisiae<\/jats:italic>, while reactions to <jats:italic>Euglena gracilis<\/jats:italic>, although highly probable, remain unconfirmed due to the lack of a provocation test.<\/jats:p>","DOI":"10.1111\/jpn.14111","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T07:43:52Z","timestamp":1741851832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Allergic Reaction to Beta\u2010Glucans in an Obese Dog: A Case Report of Confirmed and Suspected Sources"],"prefix":"10.1111","author":[{"given":"Pedro Henrique","family":"Marchi","sequence":"first","affiliation":[{"name":"Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, Pet Nutrology Research Center University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana dos Santos","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, Pet Nutrology Research Center University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo de Andrade","family":"Pr\u00edncipe","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, Pet Nutrology Research Center University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Vessecchi Amorim","family":"Zafalon","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, Pet Nutrology Research Center University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andressa Rodrigues","family":"Amaral","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Animal Science, Veterinary Nutrology Service, Veterinary Teaching Hospital University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinthia Gon\u00e7alves Lenz","family":"Cesar","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, Pet Nutrology Research Center University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falio Cesar de Carvalho","family":"Balieiro","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, Pet Nutrology Research Center University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4457-8392","authenticated-orcid":false,"given":"Thiago Henrique Annibale","family":"Vendramini","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, Pet Nutrology Research Center University of Sao Paulo Sao Paulo Brazil"},{"name":"School of Veterinary Medicine and Animal Science, Veterinary Nutrology Service, Veterinary Teaching Hospital University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"179","volume-title":"26th Congress of the European Society of Veterinary and Comparative Nutrition","author":"Amaral A. 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