{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:28:46Z","timestamp":1769120926215,"version":"3.49.0"},"reference-count":126,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The present study aimed to compare the efficacy of diclazuril and robenidine, used for decades to prevent rabbit coccidiosis, with oregano oil as a potential phytogenic alternative. Four compound feed variants were tested: one variant without additive for the control group (CG), a second supplemented with diclazuril (1\u2009mg\/kg; DG), a third with robenidine hydrochloride (66\u2009mg\/kg; RG) and a fourth added with oregano oil (75\u2009mg\/kg; OG). A total of 48 SPF rabbits aged 5 weeks were kept in groups of three animals. Four groups (12 rabbits) were assigned to each of the 4 dietary variants. At Day 10 after arrival, each animal was experimentally infected with 1300 sporulated oocysts (\n                    <jats:italic>Eimeria media, Eimeria magna, Eimeria perforans, Eimeria flavescens<\/jats:italic>\n                    and\n                    <jats:italic>Eimeria coecicola<\/jats:italic>\n                    ) originating from German rabbit stocks. Absolute excreted oocyst numbers were determined,\n                    <jats:italic>Eimeria<\/jats:italic>\n                    species identified, and reproduction rates calculated. Feed and water intake, body weight gain and feed conversion were assessed in addition to excreted faecal weights and their dry matter content. In all groups, the experimental infection resulted in markedly reduced performance parameters, changed faecal consistencies and reduced faecal weights. None of the three feed additives significantly reduced\n                    <jats:italic>Eimeria<\/jats:italic>\n                    reproduction or improved zootechnical parameters and faecal quality compared to the control animals. The present study confirms for the first time the complete and simultaneous ineffectiveness of diclazuril and robenidine due to multiple resistance in rabbit\n                    <jats:italic>Eimeria<\/jats:italic>\n                    species. Oregano as a herbal alternative for the prevention of coccidiosis in rabbits is not scientifically justified.\n                  <\/jats:p>","DOI":"10.1111\/jpn.70021","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:30:50Z","timestamp":1761658250000},"page":"112-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feed Additives for Coccidiosis Prevention: Comparative Evaluation of the Efficacy of Diclazuril, Robenidine and Oregano Oil in Growing Rabbits Experimentally Infected With\n                    <i>Eimeria<\/i>\n                    spp."],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9850-4643","authenticated-orcid":false,"given":"Florian","family":"Lohkamp","sequence":"first","affiliation":[{"name":"Institute for Animal Nutrition University of Veterinary Medicine Hannover, Foundation Hannover Germany"},{"name":"Institute for Parasitology, Centre for Infection Medicine University of Veterinary Medicine Hannover, Foundation Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4347-3161","authenticated-orcid":false,"given":"Julia","family":"Hankel","sequence":"additional","affiliation":[{"name":"Institute for Animal Nutrition University of Veterinary Medicine Hannover, Foundation Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2187-3436","authenticated-orcid":false,"given":"Andreas","family":"Beineke","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Veterinary Medicine Hannover, Foundation Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9093-1006","authenticated-orcid":false,"given":"Christina","family":"Strube","sequence":"additional","affiliation":[{"name":"Institute for Parasitology, Centre for Infection Medicine University of Veterinary Medicine Hannover, Foundation Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1198-7934","authenticated-orcid":false,"given":"Josef","family":"Kamphues","sequence":"additional","affiliation":[{"name":"Institute for Animal Nutrition University of Veterinary Medicine Hannover, Foundation Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.36380\/jwpr.2021.58"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3382\/japr.2012-00551"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.4993"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.22358\/jafs\/66141\/2013"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111586"},{"issue":"4","key":"e_1_2_10_7_1","first-page":"247","article-title":"Epidemiology and Economic Benefits of Treating Rabbits Coccidiosis in Small Farms From West Pomerania Province, Poland","volume":"60","author":"Balicka\u2010Ramisz A.","year":"2014","journal-title":"Annals of Parasitology"},{"issue":"1","key":"e_1_2_10_8_1","first-page":"97","article-title":"Coccidiosis \u2013 A Problem in Backyard Rabbitries","volume":"66","author":"Basiaga M.","year":"2020","journal-title":"Annals of Parasitology"},{"key":"e_1_2_10_9_1","first-page":"133","volume-title":"Proceedings of the 11emes Journ\u00e9es de Recherches Cunicoles Fran\u00e7aises [Proceedings of the 11th French Rabbit Research Conference]","author":"Boisot P.","year":"2005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039420410001701404"},{"issue":"1","key":"e_1_2_10_11_1","first-page":"11","article-title":"Influence of Essential Oils on Sporulation of Eimeria magna Oocysts","volume":"67","author":"Boyko O.","year":"2021","journal-title":"Annals of Parasitology"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000093790"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2010.03.007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf304149d"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2004.03.022"},{"key":"e_1_2_10_16_1","unstructured":"Capra G. M. A.Grompone N.Urruzola et al. 2010. \u201cEffect of Fresh Alfalfa in the Diet of Growing Rabbits on Growth Performance Carcass Characteristics and Fat Composition.\u201d IV Congreso Cunicultura de las Am\u00e9ricas C\u00f3rdoba Argentina."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4995\/wrs.2013.1197"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2015.02.010"},{"key":"e_1_2_10_19_1","unstructured":"Carius A.2017. \u201cFelduntersuchung zur Kokzidiose bei Rassekaninchen [Field Study on Coccidiosis in Pedigree Rabbit Breeding].\u201d Doctoral diss. Universit\u00e4t Leipzig."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079459708419208"},{"issue":"1","key":"e_1_2_10_21_1","first-page":"7","article-title":"Rotation Programmes for Coccidiosis Control","volume":"15","author":"Chapman H. 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