{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T22:04:59Z","timestamp":1784153099741,"version":"3.55.0"},"reference-count":69,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Breast\u2010fed (BF) and formula\u2010fed (FF) pigs have different intestinal morphologies and physiologies. However, how molecular expression affects intestinal morphology is imperfectly known. We compare expression profiles and functions of miRNA, mRNA, and lncRNA in the intestines of 210\u2010\n                    <jats:sc>d<\/jats:sc>\n                    \u2010old BF and FF pigs. Jejunum and duodenum villus height and mucosal thickness were significantly higher in BF pigs than FF pigs (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Of 88 identified differentially expressed (DE) miRNAs in BF pigs, 39 were up\u2010 and 49 were down\u2010regulated; of 117 lncRNAs, 53 were up\u2010 and 64 were down\u2010regulated; and of 387 mRNAs, 242 were up\u2010 and 145 were down\u2010regulated. GO and KEGG analysis revealed overlapping DE mRNA corresponding genes and target genes of DE miRNA and lncRNA to be associated with pathways involved in cold\u2010induced thermogenesis, digestion, and xenobiotics metabolism. Gene families (e.g.,\n                    <jats:italic>UGT<\/jats:italic>\n                    ,\n                    <jats:italic>ABC<\/jats:italic>\n                    ,\n                    <jats:italic>AHCY<\/jats:italic>\n                    and\n                    <jats:italic>SLC<\/jats:italic>\n                    ) potentially involved in intestinal morphological development are identified. Further analysis indicates that the\n                    <jats:italic>CYP1A1<\/jats:italic>\n                    \u2010\n                    <jats:italic>LOC100515741<\/jats:italic>\n                    \/\n                    <jats:italic>LOC100622246<\/jats:italic>\n                    \/\n                    <jats:italic>LOC100739163<\/jats:italic>\n                    and\n                    <jats:italic>AHCYL2\u2010<\/jats:italic>\n                    miR\u2010145\u20103p network may regulate the development of intestinal morphology in pigs. Collectively, these results improve our understanding of the possible long\u2010term health effects of specific alterable early\u2010life risk factors and exposures.\n                  <\/jats:p>","DOI":"10.1111\/jpn.70072","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T19:14:07Z","timestamp":1779045247000},"page":"582-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive Analysis of miRNAs, mRNAs, and lncRNAs in Intestines of Breast\u2010 and Formula\u2010Fed Pigs"],"prefix":"10.1111","volume":"110","author":[{"given":"Yuzhi","family":"Huang","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Southwest University Chongqing 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