{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:39:49Z","timestamp":1789486789142,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372909"],"award-info":[{"award-number":["32372909"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772611"],"award-info":[{"award-number":["31772611"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The interaction effects of leucine and oils on piglets\u2019 intestinal flora and barrier function are unclear. The objective of this study was to examine the impact of administering leucine and oil to pregnant sows on offspring intestinal well\u2010being. At 107 days of gestation, 68 sows were randomly divided into four dietary treatments: a basal diet, a basal diet with 1% leucine, an oil\u2010replenished diet (5.2% soybean oil), and an oil\u2010replenished diet with 1% leucine. Piglets were sampled at the end of lactation. Results showed that maternal supplementation with leucine and oil significantly improved intestinal morphogenesis. The treatments significantly reduced malondialdehyde (MDA) levels and enhanced intestinal antioxidant status. Leucine upregulated the expression of nuclear factor erythroid 2\u2010related factor 2 (\n                    <jats:italic>Nrf2<\/jats:italic>\n                    ) and downregulated Kelch\u2010like ECH\u2010associated protein 1 (\n                    <jats:italic>Keap1<\/jats:italic>\n                    ), thereby improving the\n                    <jats:italic>Nrf2<\/jats:italic>\n                    signalling pathway. It also decreased the expression of nuclear factor kappa B (\n                    <jats:italic>NF\u2010\u03baB<\/jats:italic>\n                    ) subunits (\n                    <jats:italic>NF\u2010\u03baB1<\/jats:italic>\n                    and\n                    <jats:italic>NF\u2010\u03baB2<\/jats:italic>\n                    ), downregulating the transcription of oxidative\u2010related genes. Furthermore, oil and leucine enriched beneficial gut bacteria, leading to synergistically higher levels of short\u2010chain fatty acids (SCFAs). Maternal dietary supplementation with soybean oil and leucine during late gestation and lactation exerts a profound, synergistic impact on the offspring's intestinal health. This integrated strategy provides theoretical support and a practical nutritional approach for precision management in pig farming.\n                  <\/jats:p>","DOI":"10.1111\/jpn.70088","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:49:52Z","timestamp":1783540192000},"page":"763-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Supplementation With Oil and Leucine Enhance the Gut Microbiota and Barrier of Offspring During Late Gestation and Lactation of Sows"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1335-1114","authenticated-orcid":false,"given":"Zexuan","family":"Gan","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Northeast Agricultural University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northeast Agricultural University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyuan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northeast Agricultural University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"lin","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northeast Agricultural University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingquan","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northeast Agricultural University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northeast Agricultural University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17030562"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.795101"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10010049"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1276790"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2012.153"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2024.01.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01767"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13051151"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11020402"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1241259"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.651303"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-023-01812-4"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12464"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2021.108751"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.575685"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140320"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01014-8"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.12.035"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuad039"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731111000176"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11102781"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2020.102182"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani9040125"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010020218"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.883107"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2023.109060"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjnut.2023.03.034"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxaa006"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01165-z"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104248"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pez296"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.114341"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2228045"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11071373"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1414486"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054716"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2020.10.012"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3fo03899h"}],"container-title":["Journal of Animal Physiology and Animal Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpn.70088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpn.70088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpn.70088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:21:00Z","timestamp":1789478460000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpn.70088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jpn.70088"],"URL":"https:\/\/doi.org\/10.1111\/jpn.70088","archive":["Portico"],"relation":{},"ISSN":["0931-2439","1439-0396"],"issn-type":[{"value":"0931-2439","type":"print"},{"value":"1439-0396","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"assertion":[{"value":"2025-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}