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In this work, response surface methodology (RSM) was employed to optimize the ultrasound\u2010assisted extraction (UAE) procedures to obtain phenolic compounds from\n                    <jats:italic>Sargassum carpophyllum<\/jats:italic>\n                    , a brown alga widely growing on the coastline of Asian countries. The effects of four extraction variables including ethanol concentration (EtOH%) in the solvent, liquid\u2013solid ratio, ultrasonic power, and duty cycle ratio (DCR) were evaluated using a central composite design (CCD), with the total phenol content (TPC) and antioxidant activity as the two responses. Two quadratic regression models were generated, and the optimum extraction conditions for the highest TPC and antioxidant activity were 50% ethanol, a 40\u2009mL \u00b7 g\n                    <jats:sup>\u22121<\/jats:sup>\n                    of liquid\u2013solid ratio, 260\u2009W, and a 5\/6 DCR. The corresponding predicted TPC and antioxidant activity were 2.884\u2009mg phloroglucinol (PHG) \u00b7 g\n                    <jats:sup>\u22121<\/jats:sup>\n                    algae and 3.188\u2009mg Trolox \u00b7 g\n                    <jats:sup>\u22121<\/jats:sup>\n                    algae, respectively, which were in close agreement with the experimental validation values of 2.907\u2009mg PHG \u00b7 g\n                    <jats:sup>\u22121<\/jats:sup>\n                    algae and 3.267\u2009mg Trolox \u00b7 g\n                    <jats:sup>\u22121<\/jats:sup>\n                    algae, respectively. The results suggested that the two regression models could sufficiently describe the UAE procedure and optimize the TPC and antioxidant activity. Results of the Fourier Transform Infrared Spectrometer (FTIR) spectra revealed that phenolic compounds were the major composition of the optimized extract. This work provides essential knowledge in phenolic compounds extraction from\n                    <jats:italic>S. carpophyllum<\/jats:italic>\n                    through mathematical modeling and could be a useful reference for developing upscale UAE procedures.\n                  <\/jats:p>","DOI":"10.1111\/jpy.70175","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:55:14Z","timestamp":1779116114000},"page":"855-867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimization of ultrasound\u2010assisted extraction of phenolic compounds from\n                    <i>Sargassum carpophyllum<\/i>\n                    using response surface methodology"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9057-6318","authenticated-orcid":false,"given":"Xin","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Tropical Marine Ecosystem and Bioresource Fourth Institute of Oceanography, Ministry of Natural Resources, The First Keyan Rd of Marine Scientific Research Innovation Park  Beihai Guangxi China"},{"name":"Guangxi Key Laboratory of Beibu Gulf Marine Resources, Environmental and Sustainable Development Fourth Institute of Oceanography, Ministry of Natural Resources, The First Keyan Rd of Marine Scientific Research Innovation Park  Beihai Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunjian","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Marine Ecosystem and Bioresource Fourth Institute of Oceanography, Ministry of Natural Resources, The First Keyan Rd of Marine Scientific Research Innovation Park  Beihai Guangxi China"},{"name":"Guangxi Key Laboratory of Beibu Gulf Marine Resources, Environmental and Sustainable Development Fourth Institute of Oceanography, Ministry of Natural Resources, The First Keyan Rd of Marine Scientific Research Innovation Park  Beihai Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Marine Ecosystem and Bioresource Fourth Institute of Oceanography, Ministry of Natural Resources, The First Keyan Rd of Marine Scientific Research Innovation Park  Beihai Guangxi China"},{"name":"Guangxi Key Laboratory of Beibu Gulf Marine Resources, Environmental and Sustainable Development Fourth Institute of Oceanography, Ministry of Natural Resources, The First Keyan Rd of Marine Scientific Research Innovation Park  Beihai Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enge","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Marine Ecosystem and Bioresource Fourth Institute of Oceanography, Ministry of Natural Resources, The First Keyan Rd of Marine Scientific Research Innovation Park  Beihai Guangxi China"},{"name":"Guangxi Key Laboratory of Beibu Gulf Marine Resources, Environmental and Sustainable Development Fourth Institute of Oceanography, Ministry of Natural Resources, The First Keyan Rd of Marine Scientific Research Innovation Park  Beihai Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Marine Ecosystem and Bioresource Fourth Institute of Oceanography, Ministry of Natural Resources, The First Keyan Rd of Marine Scientific Research Innovation Park  Beihai Guangxi China"},{"name":"Guangxi Key Laboratory of Beibu Gulf Marine Resources, Environmental and Sustainable Development Fourth Institute of Oceanography, Ministry of Natural Resources, The First Keyan Rd of Marine Scientific Research Innovation Park  Beihai Guangxi 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