{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:48:31Z","timestamp":1789847311796,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T00:00:00Z","timestamp":1347494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"US Army Dental Command"},{"name":"Ft Gordon DENTAC"},{"name":"3M Non-Tenured Faculty Grant"},{"name":"Nobel Biocare AB"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the potential of recombinant human bone morphogenetic protein\u20102 (rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102) soak\u2010loaded on to an absorbable collagen sponge (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>) to induce local bone formation compared with the clinical reference demineralized bone matrix (<jats:styled-content style=\"fixed-case\">DBM<\/jats:styled-content>) and to investigate potential additive\/synergistic effects of exogenous parathyroid hormone (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Critical\u2010size (8\u00a0mm), through\u2010through calvaria osteotomy defects in 160 adult male <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague\u2013<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley rats were randomized to receive one of eight interventions: rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> DBM<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ACS<\/jats:styled-content>, or serve as controls (empty defects) combined or not with systemic <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>. Ten animals from each group were followed for 4 and 8\u00a0wks for radiographic and histometric analysis. Multivariable analysis was used to assess the effect of experimental intervention and healing time on local bone formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the multivariable analysis, rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> exhibited significantly greater histologic bone formation than control (\u03b2\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>: 54.76\u00a0\u00b1\u00a05.85, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> (\u03b2\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>: 9.14\u00a0\u00b1\u00a03.31, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007) whereas <jats:styled-content style=\"fixed-case\">DBM<\/jats:styled-content> showed significantly less bone formation than control (\u03b2\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>: \u221232.32\u00a0\u00b1\u00a08.23, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Overall, <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> did not show a significant effect on bone formation (\u03b2\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>: 2.72\u00a0\u00b1\u00a06.91, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.70). No significant differences in histological defect closure were observed between 4 and 8\u00a0wks for all but the control group without <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> significantly stimulates local bone formation whereas bone formation appears significantly limited by <jats:styled-content style=\"fixed-case\">DBM<\/jats:styled-content>. Systemic application of <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> provided no discernible additive\/synergistic effects on local bone formation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12001","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T08:38:09Z","timestamp":1347525489000},"page":"243-251","source":"Crossref","is-referenced-by-count":38,"title":["Effect of bone morphogenetic protein\u20102, demineralized bone matrix and systemic parathyroid hormone (1\u201034) on local bone formation in a rat calvaria critical\u2010size defect model"],"prefix":"10.1111","volume":"48","author":[{"given":"B. W.","family":"Stancoven","sequence":"first","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration (LAPCR) Departments of Periodontics and Oral Biology Georgia Health Sciences University Augusta GA USA"},{"name":"US Army Advanced Education Program in Periodontics Ft. 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