{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:21:41Z","timestamp":1783012901779,"version":"3.54.6"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T00:00:00Z","timestamp":1347408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The present case\u2013control study aimed to evaluate comparatively the salivary and serum levels of matrix metalloproteinases (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>)\u20108 and\u2010 13 and tissue inhibitor of matrix metalloproteinase\u20101 (<jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20101) in patients with mild chronic obstructive pulmonary disease (<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>) and non\u2010<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Clinical periodontal measurements were recorded before any periodontal intervention in 36 patients with mild <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> and 20 non\u2010<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> controls admitted to Ege University Department of Chest Diseases <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> outpatient clinic (\u0130zmir, Turkey). Salivary and serum levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201013, and <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20101 were determined by immunofluorometric assay (<jats:styled-content style=\"fixed-case\">IFMA<\/jats:styled-content>) and enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>). Data were analyzed with non\u2010parametric statistical tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> were significantly older than the control group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> group showed significantly higher serum levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108 <jats:styled-content style=\"fixed-case\">IFMA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> MMP<\/jats:styled-content>\u20108\/<jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20101 <jats:styled-content style=\"fixed-case\">IFMA<\/jats:styled-content> than the control group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.005). By <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>, serum <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108\/<jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20101, and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201013 levels were similar in both groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). Salivary <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201013, and <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20101 levels were similar in both groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present findings suggest that immunodetection of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108 is dependent on the selected techniques and even with mild <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> some systemic inflammatory markers such as <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108 tend to increase. However, the present clinical periodontal and biochemical findings do not provide support for the previously proposed interaction between <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> and periodontal diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12004","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T09:59:22Z","timestamp":1347443962000},"page":"269-275","source":"Crossref","is-referenced-by-count":27,"title":["Periodontal health and serum, saliva matrix metalloproteinases in patients with mild chronic obstructive pulmonary disease"],"prefix":"10.1111","volume":"48","author":[{"given":"E.","family":"Yildirim","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dentistry Ege University \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kormi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Oulu and Oulu University Central Hospital Oulu Finland"},{"name":"Helsinki University Hospital Institute of Dentistry and Department of Oral and Maxillofacial Diseases University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6. 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