{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:23:41Z","timestamp":1774362221577,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T00:00:00Z","timestamp":1349395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>Aim(s)<\/jats:title><jats:p>To explore the relationship between biomarkers of systemic inflammation in plasma and gingival crevicular fluid in early pregnancy and the subsequent development of pre\u2010eclampsia in patients with periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A case\u2010control study was performed.\u00a0From a cohort composed of 126 pregnant women, 43 normotensive healthy pregnant women were randomly selected, and 11 cases of preeclampsia were identified. Plasmatic and gingival crevicular fluid (<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>) samples were collected in early pregnancy (11\u201314\u00a0wk gestation). The levels of interleukin\u20106 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106) and tumour necrosis factor\u2010\u03b1 (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) were measured in the plasma and <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> samples, whereas the level of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) was measured in plasma samples. Biomarkers were determined by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\u00a0assays. The data were analysed using\u00a0descriptive statistics, and the association between variables was estimated through logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was observed an association between pre\u2010eclampsia and plasmatic levels of <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.07; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.003). Additionally, pre\u2010eclampsia also was associated with\u00a0<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 levels in <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> samples in early pregnancy (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.05; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.039).\u00a0A\u00a0multiple logistic regression model suggests that\u00a0increased levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 in <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.06; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95% 1.007\u20131.117) in early pregnancy increase the risk\u00a0of developing pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion(s)<\/jats:title><jats:p>Pregnant women with periodontitis who later development pre\u2010eclampsia, shows increased levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 in <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> in plasma during early pregnancy. Periodontal disease could contribute to systemic inflammation in early pregnancy via a local increase of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and the systemic elevation of <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>. Therefore, both inflammatory markers could be involved in the relationship between periodontal disease and pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12008","type":"journal-article","created":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T04:55:09Z","timestamp":1349412909000},"page":"302-307","source":"Crossref","is-referenced-by-count":38,"title":["Increased inflammatory biomarkers in early pregnancy is associated with the development of pre\u2010eclampsia in patients with periodontitis: a case control study"],"prefix":"10.1111","volume":"48","author":[{"given":"A.","family":"Chaparro","sequence":"first","affiliation":[{"name":"Department of Periodontology, Dentistry Faculty Universidad de los Andes Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dentistry Faculty Universidad de los Andes Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Quintero","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dentistry Faculty Universidad de los Andes Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Inostroza","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dentistry Faculty Universidad de los Andes Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Public Health and Epidemiology, Dentistry Faculty Universidad de los Andes Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Carrion","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Medicine Faculty Universidad de los Andes Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Medicine Faculty Universidad de los Andes Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Serra","sequence":"additional","affiliation":[{"name":"Foetal Medicine Unit, Department of Obstetrics and Gynaecology and Laboratory of Reproductive Biology Universidad de los Andes Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. E.","family":"Illanes","sequence":"additional","affiliation":[{"name":"Foetal Medicine Unit, Department of Obstetrics and Gynaecology and Laboratory of Reproductive Biology Universidad de los Andes Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90463-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1111726"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000188408.49896.c5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1016248"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.06.014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641950701885006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02314-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050020"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01105.x"},{"key":"e_1_2_7_11_1","first-page":"1103","volume":"67","author":"Offenbacher S","year":"1996","journal-title":"J Periodontol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/002203450208100113"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000190212.87012.96"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.09.028"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01636.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.1.73"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1528"},{"key":"e_1_2_7_19_1","first-page":"16","article-title":"Periodontal inflammation: from gingivitis to systemic disease?","volume":"25","author":"Scannapieco FA","year":"2004","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1366.032"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01173.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2009.01209.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000078603.90302.4A"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063186"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.101535"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-119578"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.01.038"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38380.674340.E0"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-006-0219-y"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60659-1"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00454.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2003.00206.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2005.00253.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2007.00486.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590701327638"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1997.270-ce1162.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060362"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R400025200"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.02.022"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(02)00085-2"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi323"},{"key":"e_1_2_7_42_1","first-page":"5550","article-title":"The immunomodulating effect of interferon\u2010 intravesical instillations in preventing bladder cancer recurrence","volume":"9","author":"Giannopoulos C","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01368.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062249"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12008","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T11:45:21Z","timestamp":1698666321000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.12008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,5]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/jre.12008"],"URL":"https:\/\/doi.org\/10.1111\/jre.12008","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,5]]}}}