{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:03:13Z","timestamp":1762340593067,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T00:00:00Z","timestamp":1350000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hong Kong Research Grants Council","award":["HKU766909M","HKU768411M"],"award-info":[{"award-number":["HKU766909M","HKU768411M"]}]},{"DOI":"10.13039\/501100003803","name":"The University of Hong Kong","doi-asserted-by":"crossref","award":["200507176137","200607176038","200707176095","200907176052"],"award-info":[{"award-number":["200507176137","200607176038","200707176095","200907176052"]}],"id":[{"id":"10.13039\/501100003803","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sun Chieh Yeh Heart Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Adipocyte fatty acid\u2010binding protein (A\u2010<jats:styled-content style=\"fixed-case\">FABP<\/jats:styled-content>) is expressed in adipocytes, macrophages and microvascular endothelial cells, and it plays a central role in inflammation, atherosclerosis and metabolic responses. This pilot study investigated the effect of nonsurgical periodontal therapy on the serum levels of A\u2010<jats:styled-content style=\"fixed-case\">FABP<\/jats:styled-content> in subjects with chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A pilot clinical trial was conducted in 24 otherwise healthy Chinese subjects with moderate to severe chronic periodontitis. The treatment group (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) received nonsurgical periodontal therapy immediately, whereas in the control group (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) the treatment was delayed for 3\u00a0months. The serum levels of A\u2010FABP were measured by ELISAs. Other inflammatory and endothelial biomarkers and periodontal conditions were evaluated at baseline and at the 3\u2010month follow\u2010up appointment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A\u2010<jats:styled-content style=\"fixed-case\">FABP<\/jats:styled-content> levels decreased significantly in the treatment group compared with the control group (treatment effect: \u22121.7\u00a0ng\/mL; 95% confidence interval: \u22122.8 to \u22120.6; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.003). The treatment also significantly improved periodontal conditions but had no significant effect on other biomarkers. In the multivariable regression model, the change in the percentage of sites with detectable plaque was significantly associated with the change in the level of A\u2010<jats:styled-content style=\"fixed-case\">FABP<\/jats:styled-content> (beta: 0.04, 95% confidence interval: 0.01\u20130.06, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limitations of this pilot study, the current findings suggest that treatment of periodontitis may significantly decrease the serum levels of A\u2010<jats:styled-content style=\"fixed-case\">FABP<\/jats:styled-content>. Further longitudinal study with a large sample size is warranted to confirm this finding and elaborate the relevant clinical implications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12009","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T10:27:16Z","timestamp":1350037636000},"page":"308-314","source":"Crossref","is-referenced-by-count":8,"title":["Periodontal therapy decreases serum levels of adipocyte fatty acid\u2010binding protein in systemically healthy subjects: a pilot clinical trial"],"prefix":"10.1111","volume":"48","author":[{"given":"X.","family":"Li","sequence":"first","affiliation":[{"name":"Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. F.","family":"Tse","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. H.","family":"Yiu","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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