{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:04:31Z","timestamp":1790024671103,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T00:00:00Z","timestamp":1349222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The aim of this study was to measure melatonin levels in the gingival crevicular fluid and saliva of subjects with healthy periodontal tissues, plaque\u2010induced gingival inflammation, chronic periodontitis and aggressive periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 70 subjects were examined and assigned to four groups: healthy periodontium (10 subjects); plaque\u2010induced gingival inflammation (20 subjects); chronic periodontitis (20 subjects); and aggressive periodontitis (20 subjects). Gingival crevicular fluid and saliva samples were collected from each subject and analyzed using<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The melatonin levels in both gingival crevicular fluid and saliva were lower in patients with chronic periodontitis (10.4 and 12.8\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, respectively) and aggressive periodontitis (8.4 and 8.8\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, respectively) than in patients with gingivitis (13.9 and 17.6\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, respectively) and in healthy subjects (16.6 and 22.9\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, respectively). The mean melatonin levels in both gingival crevicular fluid and saliva were statistically significantly higher in healthy patients compared with patients with chronic periodontitis and aggressive periodontitis; however, there was no significant difference in the plaque\u2010induced gingival inflammation between the study groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The melatonin levels in gingival crevicular fluid and saliva are decreased in diseased periodontal tissues, especially periodontitis. The melatonin level was lowest in the aggressive periodontitis group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12010","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T00:33:08Z","timestamp":1349310788000},"page":"315-321","source":"Crossref","is-referenced-by-count":51,"title":["Melatonin levels in periodontal health and disease"],"prefix":"10.1111","volume":"48","author":[{"given":"O. 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